Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplus

Piper, Emily K., Jonsson, Nicholas N., Gondro, Cedric, Lew-Tabor, Ala E., Moolhuijzen, Paula, Vance, Megan E. and Jackson, Louise A. (2009) Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplus. Clinical and Vaccine Immunology, 16 7: 1074-1086. doi:10.1128/CVI.00157-09


Author Piper, Emily K.
Jonsson, Nicholas N.
Gondro, Cedric
Lew-Tabor, Ala E.
Moolhuijzen, Paula
Vance, Megan E.
Jackson, Louise A.
Title Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplus
Formatted title
Immunological profiles of Bos taurus and Bos indicus cattle infested with the cattle tick, Rhipicephalus (Boophilus) microplus
Journal name Clinical and Vaccine Immunology   Check publisher's open access policy
ISSN 1556-6811
1556-679X
1071-412X
Publication date 2009-07
Sub-type Article (original research)
DOI 10.1128/CVI.00157-09
Open Access Status Not Open Access
Volume 16
Issue 7
Start page 1074
End page 1086
Total pages 13
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Formatted abstract
The cattle tick, Rhipicephalus (Boophilus) microplus, is a major threat to the improvement of cattle production in tropical and subtropical countries worldwide. Bos indicus cattle are naturally more resistant to infestation with the cattle tick than are Bos taurus breeds, although considerable variation in resistance occurs within and between breeds. It is not known which genes contribute to the resistant phenotype, nor have immune parameters involved in resistance to R. microplus been fully described for the bovine host. This study was undertaken to determine whether selected cellular and antibody parameters of the peripheral circulation differed between tick-resistant Bos indicus and tick-susceptible Bos taurus cattle following a period of tick infestations. This study demonstrated significant differences between the two breeds with respect to the percentage of cellular subsets comprising the peripheral blood mononuclear cell population, cytokine expression by peripheral blood leukocytes, and levels of tick-specific immunoglobulin G1 (IgG1) antibodies measured in the peripheral circulation. In addition to these parameters, the Affymetrix bovine genome microarray was used to analyze gene expression by peripheral blood leukocytes of these animals. The results demonstrate that the Bos indicus cattle developed a stabilized T-cell-mediated response to tick infestation evidenced by their cellular profile and leukocyte cytokine spectrum. The Bos taurus cattle demonstrated cellular and gene expression profiles consistent with a sustained innate, inflammatory response to infestation, although high tick-specific IgG1 titers suggest that these animals have also developed a T-cell response to infestation.
© 2009, American Society for Microbiology. All Rights Reserved.
Keyword Illawarra-shorthorn cattle
Probe level data
Gene-expression
Call algorithms
Salivary-gland
Resistance
Infestations
Brahman
Normalization
Microarrays
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
School of Veterinary Science Publications
 
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Created: Thu, 03 Sep 2009, 07:54:24 EST by Mr Andrew Martlew on behalf of School of Veterinary Science