One-pot controlled synthesis of biodegradable and biocompatible co-polymer micelles

Saeed, Aram Omer, Dey, Sabrina, Howdle, Steven M., Thurecht, Kristofer J. and Alexander, Cameron (2009) One-pot controlled synthesis of biodegradable and biocompatible co-polymer micelles. Journal of Materials Chemistry, 19 26: 4529-4535. doi:10.1039/b821736j


Author Saeed, Aram Omer
Dey, Sabrina
Howdle, Steven M.
Thurecht, Kristofer J.
Alexander, Cameron
Title One-pot controlled synthesis of biodegradable and biocompatible co-polymer micelles
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
1364-5501
Publication date 2009
Sub-type Article (original research)
DOI 10.1039/b821736j
Open Access Status Not Open Access
Volume 19
Issue 26
Start page 4529
End page 4535
Total pages 7
Place of publication Cambridge, England
Publisher Royal Society of Chemistry
Language eng
Subject 03 Chemical Sciences
Abstract A facile route to biocompatible poly(lactic acid-co-glycolic acid)-co-poly(ethyleneglycolmethacrylate) (PLGA–PEGMA) block co-polymers is described utilising a combination of ring-opening polymerisation (ROP) and reversible addition fragmentation transfer (RAFT) methods. A series of PLGA–PEGMA polymers varying in co-monomer content and block length were synthesised with low polydispersities. All the block co-polymers formed micelles in aqueous solution as shown by dynamic light scattering, while critical micelle concentrations were found to be in the micromolar range. The polymer micelles were able to encapsulate model drugs (carboxyfluorescein and fluorescein isothiocyanate) and selected co-polymer micelles incubated with 3T3 fibroblasts as a model cell line were rapidly taken up as indicated by fluorescence microscopy assays. The combination of the polymer chemistries opens the way to highly flexible syntheses of micellar drug carrier systems .
Keyword Fragmentation Chain Transfer
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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