Combination of immunotherapy with anaerobic bacteria for immunogene therapy of solid tumours

Xu, Jian, Liu, Xiao Song, Zhou, Shu-Feng and Wei, Ming Q. (2009) Combination of immunotherapy with anaerobic bacteria for immunogene therapy of solid tumours. Gene Therapy and Molecular Biology, 13 1: 36-52.

Author Xu, Jian
Liu, Xiao Song
Zhou, Shu-Feng
Wei, Ming Q.
Title Combination of immunotherapy with anaerobic bacteria for immunogene therapy of solid tumours
Journal name Gene Therapy and Molecular Biology   Check publisher's open access policy
ISSN 1529-9120
Publication date 2009-06
Year available 2009
Sub-type Article (original research)
Volume 13
Issue 1
Start page 36
End page 52
Total pages 15
Place of publication Athens, Greece
Publisher Cancer Therapy
Collection year 2010
Language eng
Formatted abstract
Solid tumours possess unique microenvironment characterised by defective vessels, heterogeneous tumour cell, hypoxic regions, and anaerobic metabolisms. These often become intrinsic and acquired barriers to current therapeutical approaches, but they also create an ideal condition for the growth of anaerobic bacteria, which have shown specificity in their germination and multiplication. Spores from the strictly anaerobic clostridial had demonstrated ability in tumour specific colonisation and induction of tumour lysis following intravenous delivery. Clostridial strains genetically modified to act as “Trojan horse” gene therapy vectors have been developed. Similarly, recent development in immunotherapy strategies for cancer also utilizes gene transfer to facilitate a dormant host immune response directed against the tumour. Combination of anaerobic bacteria for cancer gene therapies with immunotherapy will probably be the most promising approach that can potentially generate a prolonged anti-tumour effect beyond the immediate treatment period of gene therapy, allowing for treatment of advanced primary tumours and disseminated disease. In this review, we introduce the recent understanding of tumour microenvironment and detail the advances in the use of anaerobic bacteria for cancer gene therapies and recent studies in immuno therapy for cancers. We believe that the use of combined treatment modalities of such will provide a rational paradigm to improve upon the clinical efficacy of cancer therapy.
Keyword Tumour microenvironment
Anaerobic bacteria
Clostridial spores
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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Created: Thu, 03 Sep 2009, 07:51:19 EST by Mr Andrew Martlew on behalf of UQ Diamantina Institute