Nephron number and individual glomerular volumes in male Caucasian and African American subjects

Zimanyi, Monika A., Hoy, Wendy E., Douglas-Denton, Rebecca N., Hughson, Michael D., Holden, Libby M. and Bertram, John F. (2009) Nephron number and individual glomerular volumes in male Caucasian and African American subjects. Nephrology, Dialysis, Transplantation, 24 8: 2428-2433. doi:10.1093/ndt/gfp116


Author Zimanyi, Monika A.
Hoy, Wendy E.
Douglas-Denton, Rebecca N.
Hughson, Michael D.
Holden, Libby M.
Bertram, John F.
Title Nephron number and individual glomerular volumes in male Caucasian and African American subjects
Formatted title
Nephron number and individual glomerular volumes in male Caucasian and African American subjects
Journal name Nephrology, Dialysis, Transplantation   Check publisher's open access policy
ISSN 0931-0509
1460-2385
Publication date 2009-08
Year available 2009
Sub-type Article (original research)
DOI 10.1093/ndt/gfp116
Volume 24
Issue 8
Start page 2428
End page 2433
Total pages 6
Editor N. Lameire
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2010
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
111706 Epidemiology
111799 Public Health and Health Services not elsewhere classified
C1
920503 Health Related to Specific Ethnic Groups
920408 Health Status (e.g. Indicators of Well-Being)
Abstract Background. Glomerular hypertrophy has been described in several populations at high risk of chronic kidney disease. Total nephron (and thereby glomerular) number (Nglom) varies widely in normal adult human kidneys and is generally inversely correlated with mean glomerular volume (Vglom). However, little is known about the range of individual glomerular volumes (IVglom) within single human kidneys and the association with Nglom. The aim of the present study was to estimate IVglom in Caucasian and African Americans and identify any associations between heterogeneity in IVglom and nephron number. Methods. Using unbiased stereological techniques, IVglom was determined for 30 glomeruli in each of 24 adult male kidneys from Jackson, MS, USA (12 Caucasian and 12 African American). Half of each group had ‘high’ Nglom (>1.2 million nephrons per kidney) and the other half had ‘low’ Nglom (<600 000). Results. Caucasians with high Nglom had a relatively homogeneous distribution of IVglom as well as a relatively low mean value, while those with low Nglom had much greater heterogeneity of IVglom, as well as a larger IVglom (P < 0.0001) compared with those with high Nglom. This disparity was not apparent in African Americans, however, where subjects with both high and low Nglom showed substantial heterogeneity in IVglom and larger mean values (P = 0.95). Conclusions. High Nglom appeared to protect against glomerular enlargement and volume heterogeneity in Caucasians. However, substantial variation in IVglom and net enlargement in glomerular size in African Americans with high nephron numbers suggest that additional forces, independent of low Nglom, are driving glomerular enlargement and heterogeneity.
Formatted abstract
Background.
Glomerular hypertrophy has been described in several populations at high risk of chronic kidney disease. Total nephron (and thereby glomerular) number (Nglom) varies widely in normal adult human kidneys and is generally inversely correlated with mean glomerular volume (Vglom). However, little is known about the range of individual glomerular volumes (IVglom) within single human kidneys and the association with Nglom. The aim of the present study was to estimate IVglom in Caucasian and African Americans and identify any associations between heterogeneity in IVglom and nephron number.

Methods.
Using unbiased stereological techniques, IVglom was determined for 30 glomeruli in each of 24 adult male kidneys from Jackson, MS, USA (12 Caucasian and 12 African American). Half of each group had ‘high’ Nglom (>1.2 million nephrons per kidney) and the other half had ‘low’ Nglom (<600 000).

Results.
Caucasians with high Nglom had a relatively homogeneous distribution of IVglom as well as a relatively low mean value, while those with low Nglom had much greater heterogeneity of IVglom, as well as a larger IVglom (P < 0.0001) compared with those with high Nglom. This disparity was not apparent in African Americans, however, where subjects with both high and low Nglom showed substantial heterogeneity in IVglom and larger mean values (P = 0.95).

Conclusions.
High Nglom appeared to protect against glomerular enlargement and volume heterogeneity in Caucasians. However, substantial variation in IVglom and net enlargement in glomerular size in African Americans with high nephron numbers suggest that additional forces, independent of low Nglom, are driving glomerular enlargement and heterogeneity.
© The Author [2009]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Keyword African American
Caucasian
Glomerular volume
Nephron number
Stereology
Diabetic nephropathy
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 07:47:03 EST by Mr Andrew Martlew on behalf of Medicine - Royal Brisbane and Women's Hospital