Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure: The French E3N cohort

Kvaskoff, Marina, Mesrine, Sylvie, Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine (2009) Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure: The French E3N cohort. International Journal of Epidemiology, 38 4: 1143-1153. doi:10.1093/ije/dyp175

Author Kvaskoff, Marina
Mesrine, Sylvie
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine
Title Endometriosis risk in relation to naevi, freckles and skin sensitivity to sun exposure: The French E3N cohort
Journal name International Journal of Epidemiology   Check publisher's open access policy
ISSN 0300-5771
Publication date 2009-08
Sub-type Article (original research)
DOI 10.1093/ije/dyp175
Volume 38
Issue 4
Start page 1143
End page 1153
Total pages 11
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
Background: Endometriosis is an important women’s health issue, however its aetiology remains unknown. An association between endometriosis and cutaneous melanoma was described, possibly explained through common genetic features. To further investigate this association, we assessed the link between phenotypic traits predisposing to melanoma and the risk of endometriosis.

Methods: Using a case–control design, we analysed data from 97 215 women of the Etude Epidémiologique auprès de femmes de l’Education Nationale study, a cohort of 98 995 French women insured by a national health scheme mostly covering teachers, and aged 40–65 years at inclusion in 1990. Risk estimates were computed using unconditional logistic regression models.

Results: After adjustment for potential confounding factors, there was a positive dose–effect relationship between risk of endometriosis (reported as surgically ascertained, n¼4241) and skin sensitivity to sun exposure [moderate: odds ratio (OR) 1.09, 95% confidence interval (CI) 0.99–1.19; high: OR 1.22; 95% CI 1.10–1.36; compared with none; Ptrend<0.0001], number of naevi (few: OR 1.19, 95% CI 1.05–1.35; many: OR 1.37, 95% CI 1.21–1.55; very many: OR 1.59, 95% CI 1.37–1.83; compared with none; Ptrend<0.0001) and number of freckles (few: OR 1.08, 95% CI 1.00–1.17; very many/many: OR 1.11, 95% CI 1.03–1.20; compared with none; Ptrend¼0.005).

This study is, to our knowledge, the first to report a positive dose–effect relationship between the risk of endometriosis and skin sensitivity to sun exposure, and number of naevi and freckles. These data suggest that endometriosis and melanoma may share some genetic features.
Keyword Case-control studies
Women’s health
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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Created: Thu, 03 Sep 2009, 07:44:10 EST by Mr Andrew Martlew on behalf of School of Public Health