Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia

den Elzen, N, Buttery, C. V., Maddugoda, M. P., Ren, G and Yap, A. S. (2009) Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Molecular Biology of The Cell, 20 16: 3740-3750. doi:10.1091/mbc.E09-01-0023

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Author den Elzen, N
Buttery, C. V.
Maddugoda, M. P.
Ren, G
Yap, A. S.
Title Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia
Journal name Molecular Biology of The Cell   Check publisher's open access policy
ISSN 1059-1524
Publication date 2009-08
Year available 2009
Sub-type Article (original research)
DOI 10.1091/mbc.E09-01-0023
Open Access Status File (Publisher version)
Volume 20
Issue 16
Start page 3740
End page 3750
Total pages 11
Editor Yixian Zheng
Place of publication Maryland, USA
Publisher American Society for Cell Biology
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
0601 Biochemistry and Cell Biology
060106 Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Abstract Oriented cell division is a fundamental determinant of tissue organization. Simple epithelia divide symmetrically in the plane of the monolayer to preserve organ structure during epithelial morphogenesis and tissue turnover. For this to occur, mitotic spindles must be stringently oriented in the Z-axis, thereby establishing the perpendicular division plane between daughter cells. Spatial cues are thought to play important roles in spindle orientation, notably during asymmetric cell division. The molecular nature of the cortical cues that guide the spindle during symmetric cell division, however, is poorly understood. Here we show directly for the first time that cadherin adhesion receptors are required for planar spindle orientation in mammalian epithelia. Importantly, spindle orientation was disrupted without affecting tissue cohesion or epithelial polarity. This suggests that cadherin receptors can serve as cues for spindle orientation during symmetric cell division. We further show that disrupting cadherin function perturbed the cortical localization of APC, a microtubule-interacting protein that was required for planar spindle orientation. Together, these findings establish a novel morphogenetic function for cadherin adhesion receptors to guide spindle orientation during symmetric cell division.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 67 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Sep 2009, 07:41:42 EST by Mr Andrew Martlew on behalf of Institute for Molecular Bioscience