Prevalence of smell loss in Parkinson's disease - A multicenter study

Haehner, A., Boesveldt, S., Berendse, H. W., Mackay-Sim, A., Fleischmann, J., Silburn, P. A., Johnston, A. N., Mellick, G. D., Herting, B., Reichmann, H. and Hummel, T. (2009) Prevalence of smell loss in Parkinson's disease - A multicenter study. Parkinsonism and Related Disorders, 15 7: 490-494. doi:10.1016/j.parkreldis.2008.12.005


Author Haehner, A.
Boesveldt, S.
Berendse, H. W.
Mackay-Sim, A.
Fleischmann, J.
Silburn, P. A.
Johnston, A. N.
Mellick, G. D.
Herting, B.
Reichmann, H.
Hummel, T.
Title Prevalence of smell loss in Parkinson's disease - A multicenter study
Journal name Parkinsonism and Related Disorders   Check publisher's open access policy
ISSN 1353-8020
1873-5126
Publication date 2009-08
Sub-type Article (original research)
DOI 10.1016/j.parkreldis.2008.12.005
Volume 15
Issue 7
Start page 490
End page 494
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Previous data on the prevalence of olfactory dysfunction in Parkinson's disease (PD) range from 45% to 90%. The present multicenter study aimed to provide data on the prevalence of smell loss in a large sample of PD patients from three independent populations. Olfactory sensitivity was tested in 400 patients from Australia, Germany, and The Netherlands by means of a psychophysical olfactory test, the “Sniffin' Sticks”, which is comprised of 3 subtests of olfactory function. Out of the total number of patients 45.0% presented as functionally anosmic, 51.7% were hyposmic, whereas only 3.3% were normosmic. This indicates that 96.7% of PD patients present with significant olfactory loss when compared to young normosmic subjects. This figure falls to 74.5%, however, when adjusted to age-related norms. Thus, olfactory dysfunction should be considered as a reliable marker of the disease.
Keyword Smell
Olfaction
Parkinson's disease
Neurodegenerative disorder
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Thu, 03 Sep 2009, 07:41:22 EST by Mr Andrew Martlew on behalf of School of Medicine