Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain

Partadiredja, G., Worrall, S. and Bedi, K. S. (2009) Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain. Brain Research, 1285 22-29. doi:10.1016/j.brainres.2009.06.010


Author Partadiredja, G.
Worrall, S.
Bedi, K. S.
Title Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain
Journal name Brain Research   Check publisher's open access policy
ISSN 1872-6240
Publication date 2009-06
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.brainres.2009.06.010
Volume 1285
Start page 22
End page 29
Total pages 8
Editor Floyd E Bloom
Place of publication Netherlands
Publisher Elsevier BV
Collection year 2010
Language eng
Subject C1
9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
060107 Enzymes
060410 Neurogenetics
060407 Genome Structure and Regulation
Abstract Diet restriction of rodents during adult life is known to cause an increased life span. It has been hypothesised that this increase may be related to effects on the anti-oxidant defence systems. However, it has been suggested that undernutrition during the gestation and pre-weaning may reduce their life span as it is known to have other deleterious effects on a rodent's growth and development. We have now examined the activity levels of some anti-oxidant defence system enzymes and other markers of oxidative stress in mice that have been undernourished from conception until 21 postnatal days of age, followed in some cases by a period of nutritional rehabilitation until 61 days of age. We found that such undernutrition exerted only minimal effects on oxidative stress markers under investigation (ROS enzyme activities, GSH levels, and lipid peroxidation). Only GSH levels were significantly affected by pre-weaning undernutrition. In conclusion, pre-weaning undernutrition may regulate anti-oxidant enzymes at the transcriptional level differently from that at the post-transcriptional, translational, or post-translational levels. The possible effects that these changes at the cellular level, may have on the longevity of the animals remain of great interest and importance.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Biomedical Sciences Publications
 
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Created: Wed, 02 Sep 2009, 15:42:35 EST by Cameron Harris on behalf of School of Biomedical Sciences