Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain

Kesby, James P., Cui, Xiaoying, Ko, Pauline, McGrath, John J., Burne, Thomas H. J. and Eyles, Darryl W. (2009) Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain. Neuroscience Letters, 461 2: 155-158. doi:10.1016/j.neulet.2009.05.070


Author Kesby, James P.
Cui, Xiaoying
Ko, Pauline
McGrath, John J.
Burne, Thomas H. J.
Eyles, Darryl W.
Title Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7922
Publication date 2009-09
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.neulet.2009.05.070
Open Access Status
Volume 461
Issue 2
Start page 155
End page 158
Total pages 4
Editor S. G. Waxman
Place of publication Amsterdam, The Netherlands
Publisher Elsevier Ireland
Collection year 2010
Language eng
Subject C1
321204 Mental Health
730211 Mental health
920410 Mental Health
110903 Central Nervous System
Abstract There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to homovanillic acid (HVA). Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
Keyword Vitamin D
Development
Dopamine
COMT
Rat
Animal model
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Available online 8 June 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
 
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Created: Thu, 20 Aug 2009, 14:59:08 EST by Debra McMurtrie on behalf of School of Biomedical Sciences