Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas

Ruutu, Merja, Johansson, Bo, Grenman, Reidar and Syrjanen, Stina (2005) Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas. Oncology Reports, 14 6: 1511-1517.

Author Ruutu, Merja
Johansson, Bo
Grenman, Reidar
Syrjanen, Stina
Title Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas
Journal name Oncology Reports   Check publisher's open access policy
ISSN 1021-335X
1791-2431
Publication date 2005-12
Sub-type Article (original research)
Volume 14
Issue 6
Start page 1511
End page 1517
Total pages 7
Place of publication Athens, Greece
Publisher Spandidos Publications
Language eng
Subject 111201 Cancer Cell Biology
111299 Oncology and Carcinogenesis not elsewhere classified
Abstract cDNA arrays were used to characterize the gene expression profiles in 6 oral carcinoma cell lines (UT-SCC-10, UT-SCC-14, UT-SCC-37, UT-SCC-54A and UT-SCC-54B, UT-SCC-74) established from 5 patients with different etiological backgrounds, including young patients, classical risk factors and lichen-derived lesions. In addition, 2 human papillomavirus (HPV)-positive cell lines (hypophraryngeal cancer and HPV16 E6/E7-transformed oral keratinocytes) were similarly tested. Two distinct global gene expression profiles with down-regulated and up-regulated patterns were identified, which closely related to the etiologic backgrounds of the primary tumors. Typically in cluster analysis, interferon or interferon-related genes and T- and B-lymphocyte-related genes were up-regulated in lichen-derived carcinoma cell lines. Common to all carcinoma cell lines were 6 genes, which were up- or down-regulated (IgC mu heavy chain constant region, semaphorin, T-cell growth factor, cAMP-dependent protein kinase β-catalytic subunit, desmocollin 1A/1B precursor and recA-like protein HsRad51). In HPV-positive cell lines, 13 genes were identified with similar down-regulation as shown in our previous studies on HPV-positive genital cell lines. Importantly, all of these genes were also down-regulated in 3 of the 6 oral cancer cell lines. These data suggest that oral carcinomas with different etiological backgrounds can be distinguished by their different global gene expression patterns.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
UQ Diamantina Institute Publications
 
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Created: Wed, 05 Aug 2009, 09:03:56 EST by Margaret Gauld on behalf of UQ Diamantina Institute