Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood

Saha, Sukanta, Barnett, Adrian G., Foldi, Claire, Burne, Thomas H., Eyles, Darryl W., Buka, Stephen L. and McGrath, John J. (2009) Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood. PLoS Medicine, 6 3: 0303-0311. doi:10.1371/journal.pmed.1000040


Author Saha, Sukanta
Barnett, Adrian G.
Foldi, Claire
Burne, Thomas H.
Eyles, Darryl W.
Buka, Stephen L.
McGrath, John J.
Title Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood
Journal name PLoS Medicine   Check publisher's open access policy
ISSN 1549-1277
1549-1676
Publication date 2009-03-10
Sub-type Article (original research)
DOI 10.1371/journal.pmed.1000040
Open Access Status DOI
Volume 6
Issue 3
Start page 0303
End page 0311
Total pages 9
Place of publication San Francisco, CA, USA
Publisher Public Library of Science
Collection year 2010
Language eng
Subject C1
110999 Neurosciences not elsewhere classified
730211 Mental health
Formatted abstract
Background: Advanced paternal age (APA) is associated with an increased risk of neurodevelopmental disorders such as autism and schizophrenia, as well as with dyslexia and reduced intelligence. The aim of this study was to examine the relationship between paternal age and performance on neurocognitive measures during infancy and childhood.

Methods and Findings
: A sample of singleton children (n = 33,437) was drawn from the US Collaborative Perinatal Project. The outcome measures were assessed at 8 mo, 4 y, and 7 y (Bayley scales, Stanford Binet Intelligence Scale, Graham-Ernhart Block Sort Test, Wechsler Intelligence Scale for Children, Wide Range Achievement Test). The main analyses examined the relationship between neurocognitive measures and paternal or maternal age when adjusted for potential confounding factors. Advanced paternal age showed significant associations with poorer scores on all of the neurocognitive measures apart from the Bayley Motor score. The findings were broadly consistent in direction and effect size at all three ages. In contrast, advanced maternal age was generally associated with better scores on these same measures.

Conclusions: 
The offspring of older fathers show subtle impairments on tests of neurocognitive ability during infancy and childhood. In light of secular trends related to delayed fatherhood, the clinical implications and the mechanisms underlying these findings warrant closer scrutiny.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Created: Tue, 14 Jul 2009, 10:48:27 EST by Debra McMurtrie on behalf of Queensland Brain Institute