Erythropoietin-induced, antibody-mediated pure red cell aplasia

Rossert, Jérôme, Maroni, Brad, Aljama, Pedro, Casadevall, Nicole, Cooper, Max, Delage, Robert, Eckardt, Kai-Uwe, de Francisco, Angel Martin Luis, Hörl, Walter, Jelkmann, Wolfgang, Johnson, David, Locatelli, Francesco, Macdougall, Iain, Nissenson, Allen R., Pollock, Carol, Schellekens, Huub, Thorpe, Robin and Toffelmire, Edwin (2005) Erythropoietin-induced, antibody-mediated pure red cell aplasia. European Journal of Clinical Investigation, 35 Supp. 3: 95-99. doi:10.1111/j.1365-2362.2005.01536.x

Author Rossert, Jérôme
Maroni, Brad
Aljama, Pedro
Casadevall, Nicole
Cooper, Max
Delage, Robert
Eckardt, Kai-Uwe
de Francisco, Angel Martin Luis
Hörl, Walter
Jelkmann, Wolfgang
Johnson, David
Locatelli, Francesco
Macdougall, Iain
Nissenson, Allen R.
Pollock, Carol
Schellekens, Huub
Thorpe, Robin
Toffelmire, Edwin
Title Erythropoietin-induced, antibody-mediated pure red cell aplasia
Journal name European Journal of Clinical Investigation   Check publisher's open access policy
ISSN 0014-2972
Publication date 2005-12
Sub-type Article (original research)
DOI 10.1111/j.1365-2362.2005.01536.x
Volume 35
Issue Supp. 3
Start page 95
End page 99
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 110312 Nephrology and Urology
110202 Haematology
Abstract Pure red cell aplasia (PRCA) is a rare haematological condition that is characterized by severe aregenerative anaemia due to an almost complete cessation of red blood cell production. While antibody-mediated PRCA was extremely rare before 1998, the incidence of this disorder increased sharply after 1998 in patients receiving subcutaneous epoetin alfa produced by Ortho-Biotech and marketed outside the USA. The diagnosis of antibody-mediated PRCA relies mostly on the results of bone marrow biopsy or aspirate, which shows an absence of erythroid precursors and/or red cell maturation arrest while counts of white cell and platelet precursors are normal, and on the identification of circulating anti-erythropoietin antibodies. Retrospective analysis of PRCA cases has shown that immunosuppressive therapy can induce a disappearance of anti-erythropoietin antibodies in most patients.
Keyword Anaemia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Fri, 10 Jul 2009, 09:27:41 EST by Maria Campbell on behalf of School of Medicine