Single and multiple cholesterol gallstones and the influence of bacteria

Vitetta, L., Best, S. and Sali, A. (2000) Single and multiple cholesterol gallstones and the influence of bacteria. Medical hypotheses, 55 6: 502-506. doi:10.1054/mehy.2000.1101

Author Vitetta, L.
Best, S.
Sali, A.
Title Single and multiple cholesterol gallstones and the influence of bacteria
Journal name Medical hypotheses   Check publisher's open access policy
ISSN 0306-9877
Publication date 2000-12
Sub-type Article (original research)
DOI 10.1054/mehy.2000.1101
Volume 55
Issue 6
Start page 502
End page 506
Total pages 5
Place of publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Language eng
Subject 11 Medical and Health Sciences
Abstract Single and multiple cholesterol gallstones constitute at least 80% of the gallstone population observed at cholecystectomy in Western countries. While supersaturation of bile with cholesterol is necessary for gallstone growth, the kinetic determinant of crystal nucleation is perhaps the critical factor leading to the incidence of gallstones. Nucleation involves aggregation of nidus-forming materials like pigment precipitates and mucus proteins. In combination with cholesterol precipitates and crystal formation, gallstone propagation is enhanced. Bacterial species may augment the process of nucleation and gallstone growth by contributing specific enzyme activities resulting in the formation of insoluble precipitates in bile, or by acting as a nidus upon which the deposition of cholesterol crystals may initiate gallstone formation. The utilization of Raman microscopic techniques permits detailed mapping of the distribution of the gallstone components leading to identification and characterization of the site of nucleation. This, when coupled to molecular genetic tools such as PCR DNA amplification, would permit elucidation of the role of bacteria in vivo gallstone propagation mechanisms.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 06 Jul 2009, 14:22:16 EST by Thelma Whitbourne on behalf of School of Medicine