Chemical stability of extemporaneously compounded omeprazole formulations: A comparison of two methods of compounding

Garg, S., Svirskis, D., Al-Kabban, M., Farhan, S., Komeshi, M., Lee, J., Liu, Q., Naidoo, S. and Kairuz, T. (2009) Chemical stability of extemporaneously compounded omeprazole formulations: A comparison of two methods of compounding. International Journal of Pharmaceutical Compounding, 13 3: 250-253.

Author Garg, S.
Svirskis, D.
Al-Kabban, M.
Farhan, S.
Komeshi, M.
Lee, J.
Liu, Q.
Naidoo, S.
Kairuz, T.
Title Chemical stability of extemporaneously compounded omeprazole formulations: A comparison of two methods of compounding
Journal name International Journal of Pharmaceutical Compounding  (ERA 2012 Listed)    (ERA 2010 Rank C)   Check publisher's open access policy
Publication date 2009
Volume number 13
Issue number 3
ISSN 1092-4221
Start page 250
End page 253
Total pages 4
Editor Allen, L. V.
Place of publication United States
Publisher International Journal of Pharmaceutical Compounding
Collection year 2010
Language eng
Subject C1
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
920299 Health and Support Services not elsewhere classified
Abstract Liquid preparations of omeprazole are compounded extemporaneously for patients who cannot tolerate or have difficulty with tablets or capsules, such as those with a nasogastric tube or jejunal or feeding tube, those with a swallowing disorder, and young children and the elderly. Recommendations for preparation of a liquid from the enteric-coated pellets of omeprazole capsules are available in the literature. The pellets are dissolved in a sodium bicarbonate solution; shaking is recommended to aid dissolution. Apparently some pharmacists crush the pellets to speed up the compounding process. The aim of this study was to investigate the chemical stability of omeprazole in extemporaneously compounded liquids prepared by the grinding and shaking methods. A high-performance liquid chromatographic method was developed for evaluation of chemical stability. Samples were stored at 2°C (refrigerated conditions) or 25°C/60% relative humidity and assayed for drug concentration at 0, 1, 2, 4, and 8 weeks. The method of preparation affected the chemical stability of ome
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Fri, 19 Jun 2009, 16:37:27 EST by Charna Kovacevic on behalf of School of Pharmacy