Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria

Todd, Jonathan D., Rogers, Rachel, Li, You Guo, Wexler, Margaret, Bond, Philip L., Sun, Lei, Curson, Andrew R. J., Malin, Gill, Steinke, Michael and Johnston, Andrew W. B. (2007) Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria. Science, 315 5812: 666-669. doi:10.1126/science.1135370

Author Todd, Jonathan D.
Rogers, Rachel
Li, You Guo
Wexler, Margaret
Bond, Philip L.
Sun, Lei
Curson, Andrew R. J.
Malin, Gill
Steinke, Michael
Johnston, Andrew W. B.
Title Structural and regulatory genes required to make the gas dimethyl sulfide in bacteria
Journal name Science   Check publisher's open access policy
ISSN 1095-9203
Publication date 2007-02
Sub-type Article (original research)
DOI 10.1126/science.1135370
Volume 315
Issue 5812
Start page 666
End page 669
Total pages 4
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Language eng
Subject 060599 Microbiology not elsewhere classified
Formatted abstract
Dimethyl sulfide (DMS) is a key compound in global sulfur and carbon cycles. DMS oxidation products cause cloud nucleation and may affect weather and climate. DMS is generated largely by bacterial catabolism of dimethylsulfoniopropionate (DMSP), a secondary metabolite made by marine algae. We demonstrate that the bacterial gene dddD is required for this process and that its transcription is induced by the DMSP substrate. Cloned dddD from the marine bacterium Marinomonas and from two bacterial strains that associate with higher plants, the N2-fixing symbiont Rhizobium NGR234 and the root-colonizing Burkholderia cepacia AMMD, conferred to Escherichia coli the ability to make DMS from DMSP. The inferred enzymatic mechanism for DMS liberation involves an initial step in which DMSP is modified by addition of acyl coenzyme A, rather than the immediate release of DMS by a DMSP lyase, the previously suggested mechanism.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes "Report"

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 128 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 137 times in Scopus Article | Citations
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