Using shock waves and micro-nanostructures for gene and drug delivery

Kendall, Mark A. F. (2006). Using shock waves and micro-nanostructures for gene and drug delivery. In: Abstracts of the 4th Joint Meeting of the Acoustical Society of America and the Acoustical Society of Japan: The Journal of the Acoustical Society of America. Fourth Joint Meeting of The Acoustical Society of America and The Acoustical Society of Japan, Honolulu, Hawaii, (). 28 November - 2 December 2006. doi:10.1121/1.4787342


Author Kendall, Mark A. F.
Title of paper Using shock waves and micro-nanostructures for gene and drug delivery
Conference name Fourth Joint Meeting of The Acoustical Society of America and The Acoustical Society of Japan
Conference location Honolulu, Hawaii
Conference dates 28 November - 2 December 2006
Convener Acoustical Society of America and The Acoustical Society of Japan
Proceedings title Abstracts of the 4th Joint Meeting of the Acoustical Society of America and the Acoustical Society of Japan: The Journal of the Acoustical Society of America   Check publisher's open access policy
Publication Year 2006
Sub-type Fully published paper
DOI 10.1121/1.4787342
ISSN 0001-4966
1520-8524
Volume 120
Issue 5
Language eng
Abstract/Summary Efficiently and safely delivering biomolecules to the skin’s immunologically sensitive cells holds the promise of advancing radical new drugs, vaccines, and immunotherapies for major diseases [D. Chen et al., Expert Rev Vaccines 1(3): 89–100 (2002)]. Here I present research into using shock waves and micro‐nanostructures to meet this goal. First, I analyze the physiology and immunology of the skin target and then introduce current physical approaches for targeting these cells for the immunotherapy [M. A. F. Kendall, Vaccine May 22; 24(21): 4651–656 (2006)]. Then, I focus on biolistics—accelerating with a helium flow micro‐particles coated in DNA to ballistically penetrate the human skin in order to achieve an immunological effect [M.A.F. Kendall, Shock Waves J., 12(1), 22–30 (2002)]. I present key findings on the engineering of these devices, skin physical interactions induced by micro‐particle impact and the resultant local biological responses. Finally, I introduce a micro‐nanoprojection array patch technology, highlighting key advantages over biolistics, including the prevention of cell‐death from shock impact with key cells.
Subjects 090304 Medical Devices
110799 Immunology not elsewhere classified
Keyword shock waves
micro-nanostructures
drug delivery
Q-Index Code EX

 
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Created: Wed, 03 Jun 2009, 13:58:19 EST by Gina Velli on behalf of Aust Institute for Bioengineering & Nanotechnology