The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease

Coulson, Elizabeth, May, Linda, Sykes, Alexander and Hamlin, Adam (2009) The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist, 15 4: 317-323. doi:10.1177/1073858408331376


Author Coulson, Elizabeth
May, Linda
Sykes, Alexander
Hamlin, Adam
Title The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease
Journal name Neuroscientist   Check publisher's open access policy
ISSN 1073-8584
1089-4098
Publication date 2009-05-20
Year available 2009
Sub-type Article (original research)
DOI 10.1177/1073858408331376
Volume 15
Issue 4
Start page 317
End page 323
Total pages 7
Editor Stephen Waxman
Place of publication United States
Publisher Sage Science Press (US)
Collection year 2010
Language eng
Subject 110902 Cellular Nervous System
060103 Cell Development, Proliferation and Death
060110 Receptors and Membrane Biology
730104 Nervous system and disorders
Formatted abstract
Degeneration of basal forebrain cholinergic neurons is a common feature of Alzheimer's disease and is proposed to be an early and key event in the condition's etiology. This review discusses recent findings that strongly link the p75 neurotrophin receptor (p75NTR) to both cholinergic neuron degeneration and the production of toxic forms of amyloid-beta (Aβ), which is found deposited as amyloid plaques in the brains of Alzheimer's disease patients. Although elucidating the underlying molecular mechanisms and the clinical significance of these findings will require further experimentation, a number of possible scenarios and future research directions are presented.
Keyword Alzheimer's disease
Basal forebrain cholinergic neuron
Neurodegeneration
Neurotrophins
Transgenic mouse models
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
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Created: Thu, 28 May 2009, 10:41:43 EST by Debra McMurtrie on behalf of Queensland Brain Institute