Atherosclerotic disease is increased in recent onset rheumatoid arthritis: a critical role for inflammation

Hannawi, Suad, Haluska, Brian, Marwick, Thomas H. and Thomas, Ranjeny (2007) Atherosclerotic disease is increased in recent onset rheumatoid arthritis: a critical role for inflammation. Arthritis Research and Therapy, 9 6: R116.1-R116.9. doi:10.1186/ar2323


Author Hannawi, Suad
Haluska, Brian
Marwick, Thomas H.
Thomas, Ranjeny
Title Atherosclerotic disease is increased in recent onset rheumatoid arthritis: a critical role for inflammation
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1465-9905
1478-6354
1478-6362
Publication date 2007-11-06
Sub-type Article (original research)
DOI 10.1186/ar2323
Open Access Status DOI
Volume 9
Issue 6
Start page R116.1
End page R116.9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Rheumatoid arthritis (RA) patients have increased mortality and morbidity as a result of cardiovascular and cerebrovascular disease. What is not clear, however, is either how early accelerated atherosclerosis begins in RA or how soon risk factors must be rigorously controlled. Furthermore, given the strong relationship of vascular disease to RA mortality and of inflammation to the accelerated atherosclerosis associated with RA, it is important to evaluate indices that could serially and noninvasively quantify atherosclerotic disease in RA patients. The carotid intima-media thickness (cIMT) and plaque, measured by ultrasound, correlate closely with direct measurement of the local and systemic atherosclerotic burden. To investigate the presence of subclinical atherosclerosis in the early stages of RA, the cIMT and plaque were measured using carotid duplex scanning in 40 RA patients with disease duration < 12 months and in 40 control subjects matched for age, sex and established cardiovascular risk factors. Patients with RA had significantly higher average cIMT values and more plaque than the control group (cIMT 0.64 ± 0.13 mm versus 0.58 ± 0.09 mm, respectively; = 0.03). In RA patients, the cIMT was predicted by age and C-reactive protein level at first presentation to the clinic (R2 = 0.64). C-reactive protein was associated with age of disease onset and history of smoking. Since inflammation has been shown to predate onset of clinical RA, the accelerated atherogenic process related to inflammation may precede RA symptom onset.
Keyword Rheumatoid arthritis
Cardiovascular disease
Cerebrovascular disease
Atherosclerotic disease
Carotid intima-media thickness
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Related Editorial from publisher: http://dx.doi.org/10.1186/ar2345

 
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Created: Tue, 19 May 2009, 11:02:47 EST by Diana Guillemin on behalf of UQ Diamantina Institute