Bone health in children with inflammatory bowel disease: adjusting for bone age

Rebecca J. Hill, Denise S.K. Brookes, Peter J. Lewindon, Geoffrey D. Withers, Looi C. Ee, Frances L. Connor, Geoffrey J. Cleghorn and Peter S.W. Davies (2009) Bone health in children with inflammatory bowel disease: adjusting for bone age. Journal of Pediatric Gastroenterology and Nutrition, 48 5: 538-543. doi:10.1097/MPG.0b013e31818cb4b6

Author Rebecca J. Hill
Denise S.K. Brookes
Peter J. Lewindon
Geoffrey D. Withers
Looi C. Ee
Frances L. Connor
Geoffrey J. Cleghorn
Peter S.W. Davies
Title Bone health in children with inflammatory bowel disease: adjusting for bone age
Journal name Journal of Pediatric Gastroenterology and Nutrition   Check publisher's open access policy
ISSN 0277-2116
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1097/MPG.0b013e31818cb4b6
Volume 48
Issue 5
Start page 538
End page 543
Total pages 6
Editor Alfredo Guarino
Judith M Sondheimer
Place of publication United States
Publisher Lippincott William & Wilkins
Collection year 2010
Language eng
Subject 110307 Gastroenterology and Hepatology
920116 Skeletal System and Disorders (incl. Arthritis)
Abstract Objectives: Clinical results of bone mineral density for children with inflammatory bowel disease are commonly reported using reference data for chronological age. It is known that these children, particularly those with Crohn disease, experience delayed growth and maturation. Therefore, it is more appropriate to compare clinical results with bone age rather than chronological age. Materials and Methods: Areal bone mineral density (aBMD) was measured using dual energy x-ray absorptiometry, and bone age was assessed using the Tanner-Whitehouse 3 method from a standard hand/wrist radiograph. Results were available for 44 children ages 7.99 to 16.89 years. Areal bone mineral density measurements were converted to z scores using both chronological and bone ages for each subject. Results: Areal bone mineral density z scores calculated using bone age, as opposed to chronological age, were significantly improved for both the total body and lumbar spine regions of interest. When subjects were grouped according to diagnosis, bone age generated z scores remained significantly improved for those with Crohn disease but not for those diagnosed with ulcerative colitis. Grouping of children with Crohn disease into younger and older ages produced significantly higher z scores using bone age compared with chronological for the older age group, but not the younger age group. Conclusions: Our findings, in accordance with those presented in the literature, suggest that aBMD results in children with Crohn disease should include the consideration of bone age, rather than merely chronological age. Bone size, although not as easily available, would also be an important consideration for interpreting results in paediatric populations. (C) 2009 Lippincott Williams & Wilkins, Inc.
Keyword Bone Age
bone mineral density
Crohn disease
dual energy X-ray absorptiometry
ulcerative colitis
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 12 May 2009, 14:01:37 EST by Lisa Hennell on behalf of School of Medicine