Toll-like receptors in ischemia-reperfusion injury

Arumugam, Thiruma V., Okun, Eitan, Tang, Sung-Chun, Thundyil, John, Taylor, Stephen M. and Woodruff, Trent M. (2009) Toll-like receptors in ischemia-reperfusion injury. Shock, 32 1: 4-16. doi:10.1097/SHK.0b013e318193e333

Author Arumugam, Thiruma V.
Okun, Eitan
Tang, Sung-Chun
Thundyil, John
Taylor, Stephen M.
Woodruff, Trent M.
Title Toll-like receptors in ischemia-reperfusion injury
Journal name Shock   Check publisher's open access policy
ISSN 1073-2322
Publication date 2009-07
Sub-type Article (original research)
DOI 10.1097/SHK.0b013e318193e333
Volume 32
Issue 1
Start page 4
End page 16
Total pages 13
Editor Irshad H. Chaudry
Place of publication United States
Publisher Lippincott Williams & Wilkins
Collection year 2009
Language eng
Subject C1
060804 Animal Immunology
920108 Immune System and Allergy
Abstract Ischemia-reperfusion (I/R) injuries are implicated in a large array of pathological conditions such as myocardial infarction, cerebral stroke, and hepatic, renal, and intestinal ischemia, as well as following cardiovascular and transplant surgeries. The hallmark of these pathologies is excessive inflammation. Toll-like receptors (TLRs) are recognized as one of the main contributors to pathogen-induced inflammation and, more recently, injury-induced inflammation. Endogenous ligands such as low-molecular hyaluronic acid, fibronectin, heat shock protein 70, and heparin sulfate were all found to be cleaved in the inflamed tissue and to activate TLR2 and TLR4, initiating an inflammatory response even in the absence of pathogens and infiltrating immune cells. In this review, we discuss the contribution of TLR activation in hepatic, renal, cerebral, intestinal, and myocardial I/R injuries. A greater understanding of the role of TLRs in I/R injuries may aid in the development of specific TLR-targeted therapeutics to treat these conditions.
Keyword Toll-like Receptor
Ischemia-reperfusion Injury
Myocardial Infarction
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 144 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 17 Apr 2009, 13:13:39 EST by Shirley Rey on behalf of School of Biomedical Sciences