Hydrophobic functional group initiated helical mesostructured silica for controlled drug release

Zhang, Lei, Qiao, Shizhang, Jin, Yonggang, Cheng, Lina, Yan, Zifeng and Lu, Gao Qing (2008) Hydrophobic functional group initiated helical mesostructured silica for controlled drug release. Advanced Functional Materials, 18 23: 3834-3842. doi:10.1002/adfm.200800631


Author Zhang, Lei
Qiao, Shizhang
Jin, Yonggang
Cheng, Lina
Yan, Zifeng
Lu, Gao Qing
Title Hydrophobic functional group initiated helical mesostructured silica for controlled drug release
Journal name Advanced Functional Materials   Check publisher's open access policy
ISSN 1616-301X
1616-3028
Publication date 2008-12-08
Sub-type Article (original research)
DOI 10.1002/adfm.200800631
Volume 18
Issue 23
Start page 3834
End page 3842
Total pages 9
Editor P. Gregory
Place of publication Weinheim, Germany
Publisher Wiley - VCH Verlag
Collection year 2009
Language eng
Subject C1
860899 Human Pharmaceutical Products not elsewhere classified
100708 Nanomaterials
0303 Macromolecular and Materials Chemistry
0904 Chemical Engineering
0912 Materials Engineering
Formatted abstract
In this paper a novel one-step synthetic pathway that controls both functionality and morphology of functionalized periodic helical mesostructured silicas by the co-condensation of tetraethoxysilane and hydrophobic organoalkoxysilane using achiral surfactants as templates is reported. In contrast to previous methods, the hydrophobic interaction between hydrophobic functional groups and the surfactant as well as the intercalation of hydrophobic groups into the micelles are proposed to lead to the formation of helical mesostructures. This study demonstrates that hydrophobic interaction and intercalation can promote the production of long cylindrical micelles, and that the formation of helical rod-like morphology is attributed to the spiral transformation from bundles of hexagonally-arrayed and straight rod-like composite micelles due to the reduction in surface free energy. It is also revealed that small amounts of mercaptopropyltrimethoxysilane, vinyltrimethoxysilane, and phenyltrimethoxysilane can cause the formation of helical mesostructures. Furthermore, the helical mesostructured silicas are employed as drug carriers for the release study of the model drug aspirin, and the results show that the drug release rate can be controlled by the morphology and helicity of the materials.
© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keyword Chiral mesoporous silica
Co-condensation
Organic functionalization
Morphology
Delivery
Nanoparticles
Surfactant
Organosilicas
Organization
Supports
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 15 Apr 2009, 14:08:34 EST by Vicki Thompson on behalf of School of Chemical Engineering