Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis

Wang, Conan K. L., Colgrave, Michelle L., Gustafson, Kirk R., Ireland, David C., Goransson, Ulf and Craik, David J. (2008) Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis. Journal of Natural Products, 71 1: 47-52. doi:10.1021/np070393g


Author Wang, Conan K. L.
Colgrave, Michelle L.
Gustafson, Kirk R.
Ireland, David C.
Goransson, Ulf
Craik, David J.
Title Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis
Formatted title
Anti-HIV Cyclotides from the Chinese Medicinal Herb Viola yedonensis
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 0163-3864
Publication date 2008-01
Year available 2008
Sub-type Article (original research)
DOI 10.1021/np070393g
Open Access Status
Volume 71
Issue 1
Start page 47
End page 52
Total pages 6
Editor A. Douglas Kinghorn
Place of publication Washigton, DC
Publisher American Chemical Society and American Society of Pharmacognosy
Collection year 2009
Language eng
Subject C1
030401 Biologically Active Molecules
970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Abstract Cyclotides are macrocyclic plant peptides characterized by a knotted arrangement of three disulfide bonds. They display a range of interesting bioactivities, including anti-HIV and insecticidal activities. More than 100 different cyclotides have been isolated from two phylogenetically distant plant families, the Rubiaceae and Violaceae. In this study we have characterized the cyclotides from Viola yedoensis, an important Chinese herb from the Violaceae family that has been reported to contain potential anti-HIV agents. From V. yedoensis five new and three known cyclotides were identified and shown to have anti-HIV activity. The most active of these is cycloviolacin Y5, which is one of the most potent of all cyclotides tested so far using in vitro XTT-based anti-HIV assays. Cycloviolacin Y5 is the most hydrophobic of the cyclotides from V. yedoensis. We show that there is a positive correlation between the hydrophobicity and the anti-HIV activity of the new cyclotides and that this trend tracks with their ability to disrupt membranes, as judged from hemolytic assays on human erythrocytes.
Keyword clyclotides
plant peptides
viola yedonensis
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 15 Apr 2009, 13:54:46 EST by Jennifer Greder on behalf of Institute for Molecular Bioscience