Silver absorption on burns after the application of Acticoat™: Data from pediatric patients and a porcine burn model

Wang, Xue-Qing, Kempf, Margit, Mott, Jonathon, Chang, Hong-En, Francis, Rod, Liu, Pei-Yun, Cuttle, Leila, Olszowy, Henry, Kravchuk, Olena, Mill, Julie and Kimble, Roy M. (2009) Silver absorption on burns after the application of Acticoat™: Data from pediatric patients and a porcine burn model. Journal of Burn Care and Research, 30 2: 341-348. doi:10.1097/BCR.0b013e318198a64c


Author Wang, Xue-Qing
Kempf, Margit
Mott, Jonathon
Chang, Hong-En
Francis, Rod
Liu, Pei-Yun
Cuttle, Leila
Olszowy, Henry
Kravchuk, Olena
Mill, Julie
Kimble, Roy M.
Title Silver absorption on burns after the application of Acticoat™: Data from pediatric patients and a porcine burn model
Journal name Journal of Burn Care and Research   Check publisher's open access policy
ISSN 1559-047X
1559-0488
Publication date 2009-03
Sub-type Article (original research)
DOI 10.1097/BCR.0b013e318198a64c
Volume 30
Issue 2
Start page 341
End page 348
Total pages 8
Editor Richard Gamelli
Place of publication Baltimore, MD, U.S.A.
Publisher Lippincott William & Wilkins
Collection year 2010
Language eng
Subject 321000 Clinical Sciences
C1
9201 Clinical Health (Organs, Diseases and Abnormal Conditions)
Abstract Silver dressings have been widely used to successfully prevent burn wound infection and sepsis. However, a few case studies have reported the functional abnormality and failure of vital organs, possibly caused by silver deposits. The aim of this study was to investigate the serum silver level in the pediatric burn population and also in several internal organs in a porcine burn model after the application of Acticoat. A total of 125 blood samples were collected from 46 pediatric burn patients. Thirty-six patients with a mean of 13.4% TBSA burns had a mean peak serum silver level of 114 mug/L, whereas 10 patients with a mean of 1.85% TBSA burns had an undetectable level of silver (<5.4 mug/L). Overall, serum silver levels were closely related to burn sizes. However, the highest serum silver was 735 mug/L in a 15-month-old toddler with 10% TBSA burns and the second highest was 367 mug/L in a 3-year old with 28% TBSA burns. In a porcine model with 2% TBSA burns, the mean peak silver level was 38 mug/L at 2 to 3 weeks after application of Acticoat and was then significantly reduced to an almost undetectable level at 6 weeks. Of a total of four pigs, silver was detected in all four livers (1.413 mug/g) and all four hearts (0.342 mug/g), three of four kidneys (1.113 mug/g), and two of four brains (0.402 mug/g). This result demonstrated that although variable, the level of serum silver was positively associated with the size of burns, and significant amounts of silver were deposited in internal organs in pigs with only 2% TBSA burns, after application of Acticoat.
Keyword Sulfadiazine
Serum
Blood
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Tue, 14 Apr 2009, 15:40:46 EST