The poor penetration of topical burn agent through burn eschar on a porcine burn model

Wang, Xue-Qing, Hayes, Mark T., Kempf, Margit, Cuttle, Leila, Mill, Julie and Kimble , Roy M. (2009) The poor penetration of topical burn agent through burn eschar on a porcine burn model. Burns, 35 6: 901-902. doi:10.1016/j.burns.2008.08.022


Author Wang, Xue-Qing
Hayes, Mark T.
Kempf, Margit
Cuttle, Leila
Mill, Julie
Kimble , Roy M.
Title The poor penetration of topical burn agent through burn eschar on a porcine burn model
Journal name Burns   Check publisher's open access policy
ISSN 0305-4179
1879-1409
Publication date 2009-09-01
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1016/j.burns.2008.08.022
Volume 35
Issue 6
Start page 901
End page 902
Total pages 2
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 11 Medical and Health Sciences
Abstract We read with great interest the article entitled “Enhancing drugs absorption through third-degree previous termburnnext term wound eschar” by Manafi et al. [1]. The authors addressed the concern of previous termpoor penetrationnext term of topically applied anti-microbials through previous termburnnext term eschar and detailed the improvement of this previous termpenetrationnext term by previous termpenetrationnext term enhancers. Here, we would like to report the previous termpoor penetrationnext term of a previous termtopicalnext term agent into the viable deep dermal layer under previous termburnnext term eschar on a porcine previous termburnnext term model [2] L. Cuttle, M. Kempf, G.E. Phillips, J. Mill, M.T. Hayes and J.F. Fraser et al., A porcine deep dermal partial thickness previous termburnnext term model with hypertrophic scarring, previous termBurnsnext term 32 (2006), pp. 806–820. Article | PDF (1332 K) | View Record in Scopus | Cited By in Scopus (18)[2]. In previous termburnnext term treatment, a common practice is the previous termtopicalnext term application of either anti-microbial products or wound enhancing agents. While the activity of anti-microbial products is designed to fight against microbes on the wound surface but with the least toxicity to viable tissue, wound enhancing agents need to reach the viable tissue layer under the previous termburnnext term eschar. Many studies have reported the accelerated healing of superficial previous termburnnext term wounds and skin graft donor sites by the previous termtopicalnext term application of exogeneous growth factors [3]. It is well known that the efficacy of the previous termpenetrationnext term of a previous termtopicalnext term agent on intact skin mostly depends on the molecular size of the product [4] and [5]. While previous termburnnext term injury destroys this epidermal physiological barrier, the coagulated previous termburnnext term tissue layer on the previous termburnnext term wound surface makes it difficult for previous termtopicalnext term agents to reach viable tissue.
Keyword Letter
Burns
Porcine model
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Wed, 15 Apr 2009, 01:40:38 EST