Cough Sensors. V. Pharmacological Modulation of Cough Sensors

Mazzone, S. B. and Undem, B. J. (2008). Cough Sensors. V. Pharmacological Modulation of Cough Sensors. In K. F. Chung and J. Widdicombe (Ed.), Pharmacology and therapeutics of cough (pp. 99-127) Berlin, Germany: Springer Verlag. doi:10.1007/978-3-540-79842-2_6

Author Mazzone, S. B.
Undem, B. J.
Title of chapter Cough Sensors. V. Pharmacological Modulation of Cough Sensors
Title of book Pharmacology and therapeutics of cough
Place of Publication Berlin, Germany
Publisher Springer Verlag
Publication Year 2008
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-540-79842-2_6
Open Access Status
Year available 2008
Series Handbook of Experimental Pharmacology
ISBN 9783540798415
ISSN 0171-2004
Editor K. F. Chung
J. Widdicombe
Volume number 187
Chapter number 6
Start page 99
End page 127
Total pages 29
Total chapters 18
Collection year 2009
Language eng
Subjects B1
110901 Autonomic Nervous System
920111 Nervous System and Disorders
Abstract/Summary Abstract Several airway afferent nerve subtypes have been implicated in coughing. These include bronchopulmonary C-fibers, rapidly adapting airway mechanorecep-tors and touch-sensitive tracheal Aδ-fibers (also called cough receptors). Although the last two afferent nerve subtypes are primarily sensitive to mechanical stimuli, all can be acted upon by one or more different chemical stimuli. In this review we catalogue the chemical agents that stimulate and/or modulate the activity of the airway afferent nerves involved in cough, and describe the specific mechanisms involved in these effects. In addition, we describe the mechanisms of action of a number of chemical inhibitors of these afferent nerve subtypes, and attempt to relate this information to the regulation of coughing in health and disease.
Q-Index Code B1
Q-Index Status Confirmed Code

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Created: Tue, 14 Apr 2009, 14:14:00 EST by Shirley Rey on behalf of School of Biomedical Sciences