Pulmonary arteriopathy and idiopathic pulmonary arterial hypertension in six dogs

Zabka, T., Campbell, F. E. and Wilson, D. (2006) Pulmonary arteriopathy and idiopathic pulmonary arterial hypertension in six dogs. Veterinary Pathology, 43 4: 510-522. doi:10.1354/vp.43-4-510


Author Zabka, T.
Campbell, F. E.
Wilson, D.
Title Pulmonary arteriopathy and idiopathic pulmonary arterial hypertension in six dogs
Journal name Veterinary Pathology   Check publisher's open access policy
ISSN 0300-9858
1544-2217
Publication date 2006
Sub-type Article (original research)
DOI 10.1354/vp.43-4-510
Open Access Status Not Open Access
Volume 43
Issue 4
Start page 510
End page 522
Total pages 13
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Subject 0707 Veterinary Sciences
Abstract Pulmonary arteriopathy (PA) is the pathologic hallmark in human medicine of diffuse constrictive (medial and intimal remodeling) or multifocal complex (plexiform and dilatative lesions) arterial lesions, or both, that lead to irreversible obliteration of the arterial lumen. Clinically, PA leads to pulmonary arterial hypertension (PAH), of which idiopathic (IPAH) is one of the 5 subsets, and ultimately, to right-sided heart failure (RHF). Clinical and pathologic findings from 6 dogs with diagnosis of IPAH and PA were reviewed. These dogs were of various pure (5/6, 83%) and mixed (1/6, 17%) breeding, 5 months to 9 years (mean 5.2 years) old, and predominantly female (4/6, 67%) and reproductively intact (4/6, 67%). Doppler echocardiography (n 5 5) indicated increased pulmonary arterial pressures during systole (70–135 mm Hg, mean 98 mm Hg) and diastole (35–80 mm Hg, mean 58 mm Hg). All 6 dogs had right ventricular pressure overload, right ventricular eccentric hypertrophy, and RHF. Histologic examination confirmed the clinical diagnosis of IPAH in all dogs, revealing PA characterized by 1 of the 4 main human histologic subsets: 1) isolated medial hypertrophy (1/6, 17%); 2) medial hypertrophy-intimal thickening without the plexiform lesion (1/6, 17%); 3) medial hypertrophyintimal thickening concurrent with the plexiform lesion, which often was regionally clustered and situated near branching points of the respiratory artery, the poststenotic dilatation lesion, and vasculitis (4/6, 66%); and 4) isolated arteritis (1/6, 17%). Ancillary lesions similar to those in humans also complicated the PA (5/6, 83%). The complex lesions and ancillary exudative alveolitis seemed to be important indicators of severe, likely rapidly progressive and fatal, IPAH.
Keyword Dog
Echocardiography
Immunohistochemistry
Lung
Pathology
Plexogenic pulmonary
Arteriopathy
Primary pulmonary hypertension
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Veterinary Science Publications
 
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Created: Tue, 14 Apr 2009, 11:01:47 EST by Ms Sarada Rao on behalf of School of Veterinary Science