Effect of ethnicity and growth on ratio-based transit time surrogate ankle-brachial index marker from a Chinese children's perception

Foo, J. Y. A., Wilson, S. J., Williams, G. R., Harris, M. and Cooper, D. M. (2008) Effect of ethnicity and growth on ratio-based transit time surrogate ankle-brachial index marker from a Chinese children's perception. Acta Cardiologica, 63 3: 369-375. doi:10.2143/AC.63.3.1020315


Author Foo, J. Y. A.
Wilson, S. J.
Williams, G. R.
Harris, M.
Cooper, D. M.
Title Effect of ethnicity and growth on ratio-based transit time surrogate ankle-brachial index marker from a Chinese children's perception
Journal name Acta Cardiologica   Check publisher's open access policy
ISSN 0001-5385
Publication date 2008-06
Year available 2008
Sub-type Article (original research)
DOI 10.2143/AC.63.3.1020315
Volume 63
Issue 3
Start page 369
End page 375
Total pages 7
Editor H. Kesteloot
Place of publication Brussels, Belgium
Publisher La Societe Belge De Cardiologie
Language eng
Subject C1
0903 Biomedical Engineering
Abstract Since its introduction, ankle brachial index (ABI) measurements have been used in numerous clinical studies for its diagnostic and epidemiological values. However, conventional methods to acquire ABI are known to have limitations such as their suitability on uncooperative children when multiple prolonged monitoring is required. A simple and non-occluding technique termed pulse transit time ratio (PTTR) has been recently proposed to be a surrogate ABI marker. This methodological approach is based on the working principle of pulse transit time (PTT). It is known that age and ethnicity have confounding effects on the body proportion but little is known about their effect on the PTTR value. Methods and results - In this study, 128 healthy subjects (43 Chinese adults, 55 Caucasian and 30 Chinese children) were recruited to assess the effect of the two physiologic parameters. Statistical analyses reveal that age and ethnicity have diverse effects on the acquired transit time-related measurements. Particularly, both the PTT and PTTR parameters were influenced by age (P < 0.05) but not ethnicity (P > 0.05). However, age did not have any effect on either parameter for the adult group (P > 0.05). Conclusions - Similar to the ABI concept, the PTTR is the quotient of the transit time acquired from the lower limb and upper limb that indirectly reflects the stiffness of the respective arterial wall. Hence, the findings herein suggest that the PTTR approach shows promise to be a surrogate ABI marker.
Keyword peripheral arterial disease
pulse timing characteristics
age related changes
pressure index
blood pressure
Distensibility
Hypertension
Severity
urban
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Information Technology and Electrical Engineering Publications
 
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