Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response

Bell, Melissa J., Brennan, Rebekah, Miles, John J., Moss, Denis J., Burrows, Jacqueline M. and Burrows, Scott R. (2008) Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response. The Journal of Infectious Diseases, 197 11: 1594-1597. doi:10.1086/587848


Author Bell, Melissa J.
Brennan, Rebekah
Miles, John J.
Moss, Denis J.
Burrows, Jacqueline M.
Burrows, Scott R.
Title Widespread sequence variation in Epstein-Barr virus nuclear antigen 1 influences the antiviral T cell response
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 2008-06-01
Year available 2008
Sub-type Article (original research)
DOI 10.1086/587848
Volume 197
Issue 11
Start page 1594
End page 1597
Total pages 4
Editor M.S. Hirsch
Place of publication Chicago, IL, U.S.A.
Publisher University of Chicago Press
Collection year 2009
Language eng
Subject C1
920109 Infectious Diseases
110804 Medical Virology
Abstract Epstein‐Barr virus (EBV) nuclear antigen (EBNA) 1 is perhaps the most widely studied EBV protein, because of its critical role in maintaining the EBV episome and its expression in all EBV‐associated malignancies. Much of this research has focused exclusively on the EBV wild‐type (wt) strain (B95‐8). Sequence analysis of the gene encoding for EBNA1 in EBV isolates from 43 Caucasians has now revealed considerable EBNA1 sequence divergence from the EBV wt strain in the majority of isolates from this population group. Importantly, T cell recognition of an endogenously processed HLA‐B8–binding EBNA1 epitope was greatly influenced by this sequence polymorphism.
Keyword Lymphocytes
Expression
EBNA-1
genome
Genes
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes electronically published 11 April 2008. -- Author Rebekah Brennan is affiliated with UQ School of Medicine, not not listed.

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Thu, 09 Apr 2009, 11:30:03 EST by Amanda Jones on behalf of School of Medicine