A novel switch region regulated H-ras membrane orientation and signal output

Abankwa, Daniel, Hanzal-Bayer, Michael, Ariotti, Nicolas, Plowman, Sarah J., Gorfe, Alemayehu A, Parton, Robert G., McCammon, J. Andrew and Hancock, John F. (2008) A novel switch region regulated H-ras membrane orientation and signal output. The EMBO journal, 27 5: 727-735.


Author Abankwa, Daniel
Hanzal-Bayer, Michael
Ariotti, Nicolas
Plowman, Sarah J.
Gorfe, Alemayehu A
Parton, Robert G.
McCammon, J. Andrew
Hancock, John F.
Title A novel switch region regulated H-ras membrane orientation and signal output
Journal name The EMBO journal  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2008-02-14
Sub-type Article
Year available 2008
DOI 10.1038/emboj.2008.10
Volume number 27
Issue number 5
ISSN 0261-4189
1460-2075
Start page 727
End page 735
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2009
Language eng
Subject C1
270104 Membrane Biology
730108 Cancer and related disorders
Abstract The plasma membrane nanoscale distribution of H-ras is regulated by guanine nucleotide binding. To explore the structural basis of H-ras membrane organization, we combined molecular dynamic simulations and medium-throughput FRET measurements on live cells.
Keyword FRET
microdomain
nanocluster
plasma membrane
Ras
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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