Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial

Broom, Jennifer, Woods, Marion, Allworth, Anthony, McCarthy, James, Faoagali, Joan, Macdonald, Sarah and Pithie, Alan (2008) Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial. Scandinavian Journal of Infectious Diseases, 40 5: 399-406. doi:10.1080/00365540701756953


Author Broom, Jennifer
Woods, Marion
Allworth, Anthony
McCarthy, James
Faoagali, Joan
Macdonald, Sarah
Pithie, Alan
Title Ethanol lock therapy to treat tunnelled central venous catheter-associated blood stream infections: Results from a prospective trial
Journal name Scandinavian Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0036-5548
1651-1980
Publication date 2008-01-01
Year available 2008
Sub-type Article (original research)
DOI 10.1080/00365540701756953
Volume 40
Issue 5
Start page 399
End page 406
Total pages 8
Editor S. R. Norrby
Place of publication United Kingdom
Publisher Informa Healthcare
Collection year 2009
Language eng
Subject C1
730101 Infectious diseases
110309 Infectious Diseases
Abstract In order to assess the efficacy of 70% ethanol locks in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bloodstream infections, a pilot study of 19 patients was performed prospectively using ethanol locks for 5 d in addition to antibiotic therapy to treat tunnelled central venous catheter-associated bacteraemia. 12 patients had mono-microbial infections and 7 had polymicrobial isolates. 17 of 19 patients completed ethanol lock therapy. 15 of 17 patients completing ethanol lock therapy had no recurrence of the original organism and retained their catheter for a median of 36 and an average of 47 d following initiation of ethanol lock therapy. These results demonstrate the safety and potential efficacy of this technique against a broad range of potentially virulent organisms. The intervention was acceptable to both staff and patients with no significant side-effects. These preliminary results from our prospective pilot study suggest that ethanol lock therapy is safe and easily integrated into clinical practice, and may have utility in treating central venous catheter-associated infections, avoiding removal of catheters in patients requiring long-term venous access.
Keyword Ethanol lock therapy
tunnelled central venous catheter-associated blood stream infections
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Mon, 06 Apr 2009, 21:18:27 EST by Amy Wong on behalf of Medicine - Royal Brisbane and Women's Hospital