Involvement of homeobox genes in mammalian sexual development

Svingen, T. and Koopman, P. (2006) Involvement of homeobox genes in mammalian sexual development. Sexual Development, 1 1: 12-23. doi:10.1159/000096235


Author Svingen, T.
Koopman, P.
Title Involvement of homeobox genes in mammalian sexual development
Journal name Sexual Development   Check publisher's open access policy
ISSN 1661-5425
Publication date 2006
Sub-type Article (original research)
DOI 10.1159/000096235
Volume 1
Issue 1
Start page 12
End page 23
Total pages 12
Place of publication Basal, Switzerland
Publisher S. Karger
Collection year 2009
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
060403 Developmental Genetics (incl. Sex Determination)
Abstract In eutherian mammals, sexual development hinges on the differentiation of the gonadal primordia into either testes or ovaries, in turn determined by the activity of the Y-linked gene Sry. Organogenesis of the gonads requires input from a complex network of morphogenetic signals, many of which are still uncharacterised. Homeobox genes are known to play important roles in embryo morphogenesis and organogenesis in a number of systems. Here, we review current data relating to possible roles of the extended homeobox gene family on gonad development, sex-specific morphogenesis and gametogenesis, and speculate that these genes may play a broader role in these processes than is currently suspected.
Keyword Gonadogenesis
homeobox
Sex Determination
Sexual development
Gametogenesis
Hox genes
Rhox genes
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Mon, 06 Apr 2009, 11:17:07 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience