An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36

te Velde, Saskia, J., van Rossum, Elisabeth F. C., Voorhoeve, Paul G., Twisk, Jos W. R., Delemarrevan de Waal, Henriette A., Stehouwer, Coen D. A., van Mechelen, Willem, Lamberts, Steven W. J. and Kemper, Han C. G. (2005) An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36. BMC Endocrine Disorders, 5 5.1-5.9. doi:10.1186/1472-6823-5-5


Author te Velde, Saskia, J.
van Rossum, Elisabeth F. C.
Voorhoeve, Paul G.
Twisk, Jos W. R.
Delemarrevan de Waal, Henriette A.
Stehouwer, Coen D. A.
van Mechelen, Willem
Lamberts, Steven W. J.
Kemper, Han C. G.
Title An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36
Formatted title
An IGF-I promoter polymorphism modifies the relationships between birth weight and risk factors for cardiovascular disease and diabetes at age 36
Journal name BMC Endocrine Disorders   Check publisher's open access policy
ISSN 1472-6823
Publication date 2005
Sub-type Article (original research)
DOI 10.1186/1472-6823-5-5
Open Access Status DOI
Volume 5
Start page 5.1
End page 5.9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Subject 1106 Human Movement and Sports Science
Formatted abstract
Objective
To investigate whether IGF-I promoter polymorphism was associated with birth weight and risk factors for cardiovascular disease (CVD) and type 2 diabetes (T2DM), and whether the birth weight – risk factor relationship was the same for each genotype.

Design and participants
264 subjects (mean age 36 years) had data available on birth weight, IGF-I promoter polymorphism genotype, CVD and T2DM risk factors. Student's t-test and regression analyses were applied to analyse differences in birth weight and differences in the birth weight – risk factors relationship between the genotypes.

Results
Male variant carriers (VCs) of the IGF-I promoter polymorphism had a 0.2 kg lower birth weight than men with the wild type allele (p = 0.009). Of the risk factors for CVD and T2DM, solely LDL concentration was associated with the genotype for the polymorphism. Most birth weight – risk factor relationships were stronger in the VC subjects; among others the birth weight – systolic blood pressure relationship: 1 kg lower birth weight was related to an 8.0 mmHg higher systolic blood pressure

Conclusion
The polymorphism in the promoter region of the IGF-I gene is related to birth weight in men only, and to LDL concentration only. Furthermore, the genotype for this polymorphism modified the relationships between birth weight and the risk factors, especially for systolic and diastolic blood pressure.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 5

 
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Created: Mon, 06 Apr 2009, 11:06:42 EST by Ms Sarada Rao on behalf of School of Human Movement and Nutrition Sciences