Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

Pons, Véronique, Luyet, Pierre-Philippe, Morel, Etienne, Abrami, Laurence, van der Goot, F. Gisou, Parton, Robert G. and Gruenberg, Jean (2008) Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biology, 6 9: 1942-1956. doi:10.1371/journal.pbio.0060214


Author Pons, Véronique
Luyet, Pierre-Philippe
Morel, Etienne
Abrami, Laurence
van der Goot, F. Gisou
Parton, Robert G.
Gruenberg, Jean
Title Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies
Journal name PLoS Biology   Check publisher's open access policy
ISSN 1544-9173
1545-7885
Publication date 2008-09-02
Sub-type Article (original research)
DOI 10.1371/journal.pbio.0060214
Open Access Status DOI
Volume 6
Issue 9
Start page 1942
End page 1956
Total pages 15
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2009
Language eng
Subject C1
060110 Receptors and Membrane Biology
970106 Expanding Knowledge in the Biological Sciences
Abstract After internalization, ubiquitinated signaling receptors are delivered to early endosomes. There, they are sorted and incorporated into the intralumenal invaginations of nascent multivescular bodies, which function as transport intermediates to late endosomes. Receptor sorting is achieved by Hrs-an adaptor-like protein that binds membrane Ptdlns3P via a FYVE motif - and then by ESCRT complexes, which presumably also mediate the invagination process.
Keyword EARLY ENDOSOMES
INWARD VESICULATION
ENDOCYTIC PATHWAY
VESICLE FORMATION
CLATHRIN COATS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # e214

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 06 Apr 2009, 10:37:43 EST by Cody Mudgway on behalf of Institute for Molecular Bioscience