Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy—a pilot study

Bauer, Judith D and Capra, Sandra (2005) Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy—a pilot study. Supportive Care in Cancer, 13 4: 270-274. doi:10.1007/s00520-004-0746-7


Author Bauer, Judith D
Capra, Sandra
Title Nutrition intervention improves outcomes in patients with cancer cachexia receiving chemotherapy—a pilot study
Journal name Supportive Care in Cancer   Check publisher's open access policy
ISSN 0941-4355
1433-7339
Publication date 2005-12-03
Sub-type Article (original research)
DOI 10.1007/s00520-004-0746-7
Volume 13
Issue 4
Start page 270
End page 274
Total pages 5
Place of publication Berlin
Publisher Springer International
Collection year 1970
Language eng
Subject 111102 Dietetics and Nutrigenomics
11 Medical and Health Sciences
1104 Complementary and Alternative Medicine
1111 Nutrition and Dietetics
Abstract Goals of the work The aim of this study was to examine the effect of nutrition intervention on outcomes of dietary intake, body composition, nutritional status, functional capacity and quality of life in patients with cancer cachexia receiving chemotherapy. Patients and methods Patients received weekly counselling by a dietitian and were advised to consume a protein- and energy-dense oral nutritional supplement with eicosapentaenoic acid for 8 weeks. The medical oncologist determined the chemotherapy protocol. Eight patients enrolled and seven completed the study. Main results There were significant improvements in total protein intake (median change 0.3 g/kg per day, range –0.1 to 0.8 g/kg per day), total energy intake (median change 36 kJ/kg per day, range –2 to 82 kJ/kg per day), total fibre intake (median change 6.3 g/day, range –3.4 to 20.1 g/day), nutritional status (patient-generated subjective global assessment score, median change 9, range –5 to 17), Karnofsky performance status (median change 10, range 0–30) and quality of life (median change 16.7, range 0–33.3). There were clinically significant improvements in weight (median change 2.3 kg; range –2.7 to 4.5 kg) and lean body mass (median change 4.4 kg, range –4.4 to 4.7 kg), although these were not statistically significant. Change in nutritional status was significantly associated with change in quality of life, change in Karnofsky performance status and change in lean body mass. Conclusions Nutrition intervention together with chemotherapy improved outcomes in patients with pancreatic and non-small-cell lung cancer over 8 weeks. Supplement intake does not inhibit meal intake.
Keyword Cancer - patients - care
Cancer - treatment
Cancer - palliative treatment
Nutritional support
Eicosapentaenoic acid
Quality of life
Nutritional status
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Excellence in Research Australia (ERA) - Collection
 
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Created: Thu, 02 Apr 2009, 22:26:44 EST by Ms Karen Naughton on behalf of Faculty Of Health Sciences