Experimental and clinical pharmacology - Incretin mimetics and enhancers: mechanisms of action

Prins, Johannes B. (2008) Experimental and clinical pharmacology - Incretin mimetics and enhancers: mechanisms of action. Australian Prescriber, 31 4: 102-104.

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Author Prins, Johannes B.
Title Experimental and clinical pharmacology - Incretin mimetics and enhancers: mechanisms of action
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
Publication date 2008-08
Year available 2008
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 31
Issue 4
Start page 102
End page 104
Total pages 3
Place of publication Austraila
Publisher National Prescribing Service Limited
Collection year 2009
Language eng
Subject C1
110306 Endocrinology
920105 Digestive System Disorders
Abstract The incretins are peptide hormones secreted from the gut in response to food. They increase the secretion of insulin. The incretin response is reduced in patients with type 2 diabetes, so drugs acting on incretins may improve glycaemic control. Incretins are metabolised by dipeptidyl peptidase, so selectively inhibiting this enzyme increases the concentration of circulating incretins. A similar effect results from giving an incretin analogue that cannot be cleaved by dipeptidyl peptidase.
Keyword diabetes
dipeptidyl peptidase
glucagon-like peptide
glucose-dependent insulinotropic polypeptide
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 31 Mar 2009, 12:58:18 EST by Kylie Hengst on behalf of UQ Diamantina Institute