Excess Casein in the Diet Is Not the Unique Cause of Low-Grade Metabolic Acidosis: Role of a Deficit in Potassium Citrate in a Rat Model

Sabboh, Houda, Besson, Catherine, Tressol, Jean-Claude, Rémésy, Christian and Demigné, Christian (2006) Excess Casein in the Diet Is Not the Unique Cause of Low-Grade Metabolic Acidosis: Role of a Deficit in Potassium Citrate in a Rat Model. Annals of Nutrition & Metabolism, 50 3: 229-236. doi:10.1159/000090901


Author Sabboh, Houda
Besson, Catherine
Tressol, Jean-Claude
Rémésy, Christian
Demigné, Christian
Title Excess Casein in the Diet Is Not the Unique Cause of Low-Grade Metabolic Acidosis: Role of a Deficit in Potassium Citrate in a Rat Model
Journal name Annals of Nutrition & Metabolism   Check publisher's open access policy
ISSN 0250-6807
Publication date 2006
Sub-type Article (original research)
DOI 10.1159/000090901
Volume 50
Issue 3
Start page 229
End page 236
Total pages 8
Place of publication Basel
Publisher Karger
Language eng
Subject 111199 Nutrition and Dietetics not elsewhere classified
Formatted abstract
This study examined the effects of a dietary model of protein excess and K anion salt deficit on the occurrence of metabolic acidosis in rat. Rats were adapted to diets containing either 13 or 26% casein, together with mineral imbalance, through lowering K/increasing sodium/omitting alkalinizing anions. For each protein level, a group of rats was supplemented with K citrate. Dietary K citrate resulted in neutral urinary pH, whatever the protein level. Urea excretion was higher in rats adapted to 26% casein than 13% casein diets, but K citrate enhanced this excretion and suppressed ammonium elimination. No citraturia could be observed in acidotic rats, whereas K citrate greatly stimulated citraturia and 2-ketoglutarate excretion. In conclusion, low-grade metabolic acidosis can occur with a moderate protein level in the diet. K citrate was apparently less effective in rats adapted to the 26% casein level than in those adapted to the 13% casein level with regard to magnesium, citrate and 2-ketoglutarate concentrations in urine.

Copyright © 2006 S. Karger AG, Basel
Keyword Metabolic acidosis, low-grade
Protein
Potassium
Urea
Citrate
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Centre for Nutrition and Food Sciences Publications
 
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Created: Tue, 31 Mar 2009, 12:35:27 EST by Ms Julie Schofield on behalf of Centre for Nutrition and Food Sciences