Identification of genes involved with tick infestation in Bos taurus and Bos indicus

Kongsuwan, K., Piper, E. K., Bagnall, N. H., Ryan, K., Moolhuijzen, P., Bellgard, M., Lew, A., Jackson, L. and Jonsson, Nicholas N. (2008). Identification of genes involved with tick infestation in Bos taurus and Bos indicus. In: Cyril G. Gay, Paul-Pierre Pastoret and Marie-Hélène Pinard-van der Laan, Developments in Biologicals: Proceedings of this international symposium held at the World Organization for Animal Health (OIE) Headquarters. International Symposium on Animal Genomics for Animal Health, Paris, France, (77-88). 23- 25 October 2007. doi:10.1159/000317146


Author Kongsuwan, K.
Piper, E. K.
Bagnall, N. H.
Ryan, K.
Moolhuijzen, P.
Bellgard, M.
Lew, A.
Jackson, L.
Jonsson, Nicholas N.
Title of paper Identification of genes involved with tick infestation in Bos taurus and Bos indicus
Formatted title
Identification of genes involved with tick infestation in Bos taurus and Bos indicus
Conference name International Symposium on Animal Genomics for Animal Health
Conference location Paris, France
Conference dates 23- 25 October 2007
Proceedings title Developments in Biologicals: Proceedings of this international symposium held at the World Organization for Animal Health (OIE) Headquarters   Check publisher's open access policy
Journal name Developments in Biologicals   Check publisher's open access policy
Place of Publication Basel, Switzerland
Publisher S. Karger AG
Publication Year 2008
Sub-type Fully published paper
DOI 10.1159/000317146
ISBN 978-3-8055-8619-1
ISSN 1424-6074
1662-2960
Editor Cyril G. Gay
Paul-Pierre Pastoret
Marie-Hélène Pinard-van der Laan
Volume 132
Start page 77
End page 88
Total pages 12
Collection year 2009
Language eng
Formatted Abstract/Summary
Tick resistant cattle could provide a potentially sustainable and environmentally sound method of controlling cattle ticks. Advances in genomics and the availability of the bovine genome sequence open up opportunities to identify useful and selectable genes controlling cattle tick resistance. Using quantitative real-time PCR and the Affymetrix bovine array platform, differences in gene expression of skin biopsies from tick resistant Bos indicus (Brahman) and tick susceptible Bos taurus (Holstein-Friesian) cattle following tick challenge were examined. We identified 138 significant differentially-expressed genes, including several immunological/host defence genes, extracellular matrix proteins, and transcription factors as well as genes involved in lipid metabolism. Three key pathways, represented by genes differentially expressed in resistant Brahmans, were identified; the development of the cell-mediated immune response, structural integrity of the dermis and intracellular Ca2+ levels. Ca2+, which is implicated in host responses to microbial stimuli, may be required for the enhancement or fine-tuning of transcriptional activation of Ca2+-dependant host defence signalling pathways.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 27 Mar 2009, 15:55:48 EST by Narelle Poole on behalf of School of Veterinary Science