Alcohol intake and breast cancer risk : The European Prospective Investigation into Cancer and Nutrition (EPIC)

Tjonneland, Anne, Christensen, Jane, Olsen, Anja, Stripp, Connie, Thomsen, Birthe L., Overvad, Kim, Peeters, Petra H. M., van Gils, Carla H., Bueno-de-Mesquita, H. Bas, Ocke, Marga C., Thiebaut, Anne, Fournier, Agnes, Clavel-Chapelon, Francoise, Berrino, Franco, Palli, Domenico, Tumino, Rosario, Panico, Salvatore, Vineis, Paolo, Agudo, Antonio, Ardanaz, Eva, Martinez-Garcia, Carmen, Amiano, Pilar, Navarro, Carmen, Quiros, Jose R., Key, Tim J., Reeves, Gillian, Khaw, Kay-Tee, Bingham, Sheila, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Naska, Androniki, Nagel, Gabriele, Chang-Claude, Jenny, Boeing, Heiner, Lahmann, Petra H., Manjer, Jonas, Wirfalt, Elisabet, Hallmans, Goran, Johansson, Ingegerd, Lund, Eiliv, Skeie, Guri, Hjartaker, Anette, Ferrari, Pietro, Slimani, Nadia, Kaaks, Rudolf and Riboli, Elio (2007) Alcohol intake and breast cancer risk : The European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes and Control, 18 4: 361-373.


Author Tjonneland, Anne
Christensen, Jane
Olsen, Anja
Stripp, Connie
Thomsen, Birthe L.
Overvad, Kim
Peeters, Petra H. M.
van Gils, Carla H.
Bueno-de-Mesquita, H. Bas
Ocke, Marga C.
Thiebaut, Anne
Fournier, Agnes
Clavel-Chapelon, Francoise
Berrino, Franco
Palli, Domenico
Tumino, Rosario
Panico, Salvatore
Vineis, Paolo
Agudo, Antonio
Ardanaz, Eva
Martinez-Garcia, Carmen
Amiano, Pilar
Navarro, Carmen
Quiros, Jose R.
Key, Tim J.
Reeves, Gillian
Khaw, Kay-Tee
Bingham, Sheila
Trichopoulou, Antonia
Trichopoulos, Dimitrios
Naska, Androniki
Nagel, Gabriele
Chang-Claude, Jenny
Boeing, Heiner
Lahmann, Petra H.
Manjer, Jonas
Wirfalt, Elisabet
Hallmans, Goran
Johansson, Ingegerd
Lund, Eiliv
Skeie, Guri
Hjartaker, Anette
Ferrari, Pietro
Slimani, Nadia
Kaaks, Rudolf
Riboli, Elio
Title Alcohol intake and breast cancer risk : The European Prospective Investigation into Cancer and Nutrition (EPIC)
Journal name Cancer Causes and Control  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2007-05
Sub-type Article
DOI 10.1007/s10552-006-0112-9
Volume number 18
Issue number 4
ISSN 0957-5243: 1573-7225
Start page 361
End page 373
Total pages 13
Place of publication Oxford, UK
Publisher Kluwer
Language eng
Subject 1117 Public Health and Health Services
Abstract Objective Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer. Methods Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors. Results During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35–75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01–1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate. Conclusion This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer. Alcohol
Keyword Oncology
Alcohol
Breast neoplasm
Cohort study
Hormone replacement therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article
Collections: Excellence in Research Australia (ERA) - Collection
School of Population Health Publications
 
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