Optical and MRI multifunctional nanoprobe for targeting gliomas

Veiseh, Omid, Sun, Conroy, Gunn, Jonathan, Kohler, Nathan, Gabikian, Patrik, Lee, Donghoon, Bhattarai, Narayan, Ellenbogen, Richard, Sze, Raymond, Hallahan, Andrew, Olson, Jim and Zhang, Miqin (2005) Optical and MRI multifunctional nanoprobe for targeting gliomas. Nano Letters, 5 6: 1003-1008. doi:10.1021/nl0502569


Author Veiseh, Omid
Sun, Conroy
Gunn, Jonathan
Kohler, Nathan
Gabikian, Patrik
Lee, Donghoon
Bhattarai, Narayan
Ellenbogen, Richard
Sze, Raymond
Hallahan, Andrew
Olson, Jim
Zhang, Miqin
Title Optical and MRI multifunctional nanoprobe for targeting gliomas
Journal name Nano Letters   Check publisher's open access policy
ISSN 1530-6984
Publication date 2005
Sub-type Article (original research)
DOI 10.1021/nl0502569
Volume 5
Issue 6
Start page 1003
End page 1008
Total pages 6
Place of publication Washington, DC
Publisher American Chemical Society
Language eng
Subject 11 Medical and Health Sciences
Abstract A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.
Keyword Nanoprobe
Glioma cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
ERA 2012 Admin Only
School of Medicine Publications
 
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Created: Fri, 27 Mar 2009, 12:12:26 EST by Ms Karen Naughton on behalf of Faculty Of Health Sciences