Parent-collected respiratory specimens - A novel method for respiratory virus and vaccine efficacy research

Lambert, Stephen B., Allen, Kelly M. and Nolan, Terence M. (2008) Parent-collected respiratory specimens - A novel method for respiratory virus and vaccine efficacy research. Vaccine, 26 15: 1826-1831. doi:10.1016/j.vaccine.2008.01.055


Author Lambert, Stephen B.
Allen, Kelly M.
Nolan, Terence M.
Title Parent-collected respiratory specimens - A novel method for respiratory virus and vaccine efficacy research
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2008-03-28
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2008.01.055
Volume 26
Issue 15
Start page 1826
End page 1831
Total pages 6
Editor R. E. Spier
Place of publication London, United Kingdom
Publisher Elsevier Ltd.
Collection year 2009
Language eng
Subject C1
110804 Medical Virology
111706 Epidemiology
Abstract Population-based respiratory research and vaccine efficacy studies have previously required clinic or home visits when a subject had an acute respiratory illness. This method may mean parents are unwilling to enrol their child or report an illness of interest. We conducted a community-based cohort study into respiratory illnesses in 234 pre-school aged children using parent-collected specimens. Between January 2003 and January 2004 there were 563 specimens collected from 730 identified illnesses and these were tested using a panel of respiratory virus polymerase chain reaction (PCR) assays; 409 (73%) were positive for any virus. Specimens were not more likely to be positive when collected by a healthcare worker parent, when they included a throat swab, or when a very good collection technique was reported. A delay from illness onset to specimen collection of up to 5 days did not appear to impact on sensitivity of virus identification, but a delay of six or more days with minor delays in testing saw positivity fall. Combined with daily symptom diary completion and PCR testing, parent-collected specimens are an efficient and acceptable method for the conduct of future vaccine efficacy studies and other community-based respiratory virus research.
Keyword respiratory research
vaccine efficacy studies
acute respiratory illness
parent-collected specimens
virus identification
PCR testing
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Clinical Medical Virology Centre Publications
 
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Created: Fri, 27 Mar 2009, 01:45:30 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre