Dendritic cells in the thymus contribute to T-regulatory cell induction

Proietto, Anna I., van Dommelen, Serani van, Zhou, Penghui, Rizzitelli, Alexandra, D'Amico, Angela, Steptoe, Raymond J., Naik, Shalin H., Lahoud, Mireille H., Liu, Yang, Zheng, Pan, Shortman, Ken and Wu, Li (2008) Dendritic cells in the thymus contribute to T-regulatory cell induction. Proceedings of the National Academy of Sciences of the United States of America, 105 50: 19869-19874. doi:10.1073/pnas.0810268105


Author Proietto, Anna I.
van Dommelen, Serani van
Zhou, Penghui
Rizzitelli, Alexandra
D'Amico, Angela
Steptoe, Raymond J.
Naik, Shalin H.
Lahoud, Mireille H.
Liu, Yang
Zheng, Pan
Shortman, Ken
Wu, Li
Title Dendritic cells in the thymus contribute to T-regulatory cell induction
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2008-12-16
Year available 2008
Sub-type Article (original research)
DOI 10.1073/pnas.0810268105
Volume 105
Issue 50
Start page 19869
End page 19874
Total pages 6
Place of publication Washington, DC, United States
Publisher National Academy of Sciences of the United States of America
Collection year 2009
Language eng
Subject C1
110704 Cellular Immunology
920108 Immune System and Allergy
Formatted abstract
Central tolerance is established through negative selection of self-reactive thymocytes and the induction of T-regulatory cells (TRs). The role of thymic dendritic cells (TDCs) in these processes has not been clearly determined. In this study, we demonstrate that in vivo, TDCs not only play a role in negative selection but in the induction of TRs. TDCs include two conventional dendritic cell (DC) subtypes, CD8loSirpαhi/+ (CD8loSirpα+) and CD8hiSirpαlo/− (CD8loSirpα), which have different origins. We found that the CD8hiSirpα+ DCs represent a conventional DC subset that originates from the blood and migrates into the thymus. Moreover, we show that the CD8loSirpα+ DCs demonstrate a superior capacity to induce TRs in vitro. Finally, using a thymic transplantation system, we demonstrate that the DCs in the periphery can migrate into the thymus, where they efficiently induce TR generation and negative selection.
Keyword Thymic selection
Migratory dendritic cells
Tolerance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 25 Mar 2009, 16:35:55 EST by Kylie Hengst on behalf of UQ Diamantina Institute