Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B

He, Yaowu and Smith, Ross (2009) Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B. Cellular and Molecular Life Sciences, 66 7: 1239-1256. doi:10.1007/s00018-008-8532-1

Author He, Yaowu
Smith, Ross
Title Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 2009-04
Sub-type Article (original research)
DOI 10.1007/s00018-008-8532-1
Volume 66
Issue 7
Start page 1239
End page 1256
Total pages 18
Editor P. Jolles
Place of publication Basel, Switzerland
Publisher Birkhaeuser
Collection year 2009
Language eng
Subject C1
110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
970106 Expanding Knowledge in the Biological Sciences
Abstract The hnRNP A/B proteins are among the most abundant RNA-binding proteins, forming the core of the ribonucleoprotein complex that associates with nascent transcripts in eukaryotic cells. There are several paralogs in this subfamily, each of which is subject to alternative transcript splicing and post-translational modifications. The structural diversity of these proteins generates a multitude of functions that involve interactions with DNA or, more commonly, RNA. They also recruit regulatory proteins associated with pathways related to DNA and RNA metabolism, and appear to accompany transcripts throughout the life of the mRNA. We have highlighted here recent progress in elucidation of molecular mechanisms underlying the roles of these hnRNPs in a wide range of nuclear processes, including DNA replication and repair, telomere maintenance, transcription, pre-mRNA splicing, and mRNA nucleo-cytoplasmic export.
Keyword hnRNP A/B
RNA-protein interactions
DNA repair
Pre-mRNA splicing
Nucleocytoplasmic RNA export
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Wed, 25 Mar 2009, 14:42:38 EST by Jennifer Falknau on behalf of Faculty of Science