Decreasing mortality from non-Hodgkin lymphoma in Australia

Coory, M. and Gill, D. (2008) Decreasing mortality from non-Hodgkin lymphoma in Australia. Internal Medicine Journal, 38 12: 921-924. doi:10.1111/j.1445-5994.2008.01809.x


Author Coory, M.
Gill, D.
Title Decreasing mortality from non-Hodgkin lymphoma in Australia
Journal name Internal Medicine Journal   Check publisher's open access policy
ISSN 144-0903, 1445-5994
Publication date 2008-12
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1445-5994.2008.01809.x
Volume 38
Issue 12
Start page 921
End page 924
Total pages 4
Editor Jeff Szer
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2009
Language eng
Subject C1
920102 Cancer and Related Disorders
111706 Epidemiology
Abstract Based on the number of new cases (incidence), non-Hodgkin lymphoma is an increasingly common cancer in Australia and many developed countries. Until recently, mortality trends have been stable or slightly increasing. However, since the year 2000, mortality has decreased every year by an average of 5.1% per year (95% confidence interval (CI) −7.1 to −3.1%), whereas incidence has continued to increase at 0.9% per year (95%CI 0.6 to 1.2%). It was not possible with the population-based registry data available to us to untangle the causes of the decrease in mortality. The stable mortality rates during the 1990s (in the face of increasing incidence) might have been because of introduction of novel therapies such as autologous stem cell transplant for relapsed diffuse large cell lymphoma or the purine analogue-based therapy for indolent lymphomas. A plausible explanation for the large decrease in mortality since 2000 is the introduction of the monoclonal antibody rituximab.
Keyword non-Hodgkin lymphoma
epidemiology
mortality
rituximab
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Tue, 24 Mar 2009, 14:43:35 EST by Geraldine Fitzgerald on behalf of Faculty Of Health Sciences