Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites

Hughson, Michael D., Gobe, Glenda C., Hoy, Wendy E., Manning, R. Davis Jr, Douglas-Denton, Rebecca and Bertram, John F. (2008). Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites. In: 37th Annual Meeting of the American Society of Nephrology, St Louis, MO, United States, (18-28). 27 October - 1 November 2004. doi:10.1053/j.ajkd.2008.03.023

Author Hughson, Michael D.
Gobe, Glenda C.
Hoy, Wendy E.
Manning, R. Davis Jr
Douglas-Denton, Rebecca
Bertram, John F.
Title of paper Associations of glomerular number and birth weight with clinicopathological features of African Americans and whites
Conference name 37th Annual Meeting of the American Society of Nephrology
Conference location St Louis, MO, United States
Conference dates 27 October - 1 November 2004
Journal name American Journal of Kidney Diseases   Check publisher's open access policy
Place of Publication Philadelphia, PA., U.S.A.
Publisher W. B. Saunders
Publication Year 2008
Sub-type Fully published paper
DOI 10.1053/j.ajkd.2008.03.023
ISSN 0272-6386
Volume 52
Issue 1
Start page 18
End page 28
Total pages 11
Collection year 2009
Language eng
Formatted Abstract/Summary
Background: Hypertension and its cardiovascular complications affect African Americans more severely than whites, a disparity variously ascribed to low birth weight, low glomerular number, an exaggerated arteriolonephrosclerotic blood pressure response, and inflammation-induced oxidative stress.
Study Design: Case series.
Setting and Participants: Autopsy kidneys of 107 African Americans and 87 whites aged 18 to 65 years at a single medical center between 1998 and 2005. Excluded were persons with known premorbid kidney disease; pathological findings of severe arterioarteriolonephrosclerosis, nodular and diffuse diabetic glomerulosclerosis, or nonischemic cardiomyopathy.
Predictors & Outcomes:
Associations of: (1) race, age, sex, birth weight, obesity, and glomerular number (predictors) with hypertension and death from coronary artery (CAD) and cerebrovascular disease (CVD; outcomes); and (2) age, blood pressure, and race (predictors) with arteriolonephrosclerotic changes, including chronic tubulointerstitial inflammation (outcomes).
Hypertension ascertained from chart review and heart weight. Cause of death determined from chart review and autopsy findings. Birth weight obtained from birth records (115 persons). Total glomerular number (Nglom) estimated by using the dissector/fractionator technique. Arteriolosclerosis, glomerulosclerosis, cortical fibrosis, and chronic inflammation by using CD68 density were measured morphometrically.
59 African Americans (55%) and 32 whites (37%) were classified as hypertensive. CAD and CVD were the cause of death in 64 (33%) and 18 persons (9%), respectively. By using multiple linear regression, birth weight (P < 0.001) and sex (P < 0.01), but not race (P = 0.3) or age (P = 0.2), predicted Nglom (P < 0.001; adjusted r2 = 0.176). Hypertension was associated with African American race (P = 0.04), older age (P < 0.001), and male sex (P = 0.01), but not with Nglom (P = 0.9), body mass index (P = 0.9), or birth weight (P = 0.4). Hypertension was the only significant factor associated with CAD and CVD (P < 0.001 for both). Interactions of age and blood pressure with race showed that although African Americans had more severe hypertension (P < 0.001) and arteriolosclerosis (P = 0.01) at a younger age than whites, there were no significant racial differences in degrees of arteriolosclerosis, glomerulosclerosis, cortical fibrosis, or CD68 density for any level of increased blood pressure.
The study is observational and descriptive.
Conclusions: The more severe hypertension found in African Americans could not be attributed to racial differences in Nglom or birth weight. CAD and CVD death and increased arteriolonephrosclerosis, including CD68 density, were determined by using blood pressure without a significant interacting contribution from race.
Subjects C1
110312 Nephrology and Urology
920119 Urogenital System and Disorders
1103 Clinical Sciences
Keyword Hypertension
Glomerular number
Birth weight
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes "Original Investigation".

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 51 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 57 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 24 Mar 2009, 14:10:22 EST by Brenda Mason on behalf of Faculty Of Health Sciences