Refining prognosis in non–small-cell lung cancer

Larsen, Jill E., Fong, Kwun M. and Hayward, Nicholas K. (2007) Refining prognosis in non–small-cell lung cancer. The New England Journal of Medicine, 356 2: 190-190.


Author Larsen, Jill E.
Fong, Kwun M.
Hayward, Nicholas K.
Title Refining prognosis in non–small-cell lung cancer
Journal name The New England Journal of Medicine   Check publisher's open access policy
ISSN 1533-4406
0028-4793
Publication date 2007-01-11
Sub-type Letter to editor, brief commentary or brief communication
Volume 356
Issue 2
Start page 190
End page 190
Total pages 1
Place of publication Boston, U.S.
Publisher Massachusetts Medical Society
Language eng
Subject 111201 Cancer Cell Biology
111203 Cancer Genetics
11 Medical and Health Sciences
Abstract To the Editor: Potti et al. (Aug. 10 issue)1 apply a metagene model to the profiling of non–small-cell lung cancer (NSCLC) and demonstrate superior performance in predicting tumor recurrence and survival, as compared with a clinical model. We believe that the impressively contrasting results could be partially due to the incompleteness of the clinical model the authors used. Classifying NSCLC into squamous-cell carcinoma and adenocarcinoma has not been predictive for prognosis in general. However, subtypes of adenocarcinoma — bronchioloalveolar carcinoma and mixed adenocarcinoma with a bronchioloalveolar component, which account for approximately 20% of cases of early-stage NSCLC — have a much better prognosis than do other subtypes.2 Potti et al. did not consider these adenocarcinoma subtypes. In addition, the literature3 and our recent work demonstrate that the histologic grade is a significant predictor of both tumor recurrence and survival,4 and there is a high correlation between histologic features and gene-expression profiles.5 Our work also shows that incorporating the adenocarcinoma subtype and histologic grade into clinical models would provide a prediction very similar to that of a well-validated, 50-gene panel for survival.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 24 Mar 2009, 10:40:32 EST by Ms Lynette Adams on behalf of Medicine - Royal Brisbane and Women's Hospital