Fetal stem cells

O'Donoghue, Keelin and Fisk, Nicholas M. (2004) Fetal stem cells. Best Practice & Research Clinical Obstetrics & Gynaecology, 18 6: 853-875. doi:10.1016/j.bpobgyn.2004.06.010

Author O'Donoghue, Keelin
Fisk, Nicholas M.
Title Fetal stem cells
Journal name Best Practice & Research Clinical Obstetrics & Gynaecology   Check publisher's open access policy
ISSN 1521-6934
Publication date 2004-12
Sub-type Article (original research)
DOI 10.1016/j.bpobgyn.2004.06.010
Volume 18
Issue 6
Start page 853
End page 875
Total pages 23
Place of publication London, U.K.
Publisher Bailliere Tindall
Language eng
Subject 111402 Obstetrics and Gynaecology
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Fetal stem cells can be isolated from fetal blood and bone marrow as well as from other fetal tissues, including liver and kidney. Fetal blood is a rich source of haemopoietic stem cells (HSC), which proliferate more rapidly than those in cord blood or adult bone marrow. First trimester fetal blood also contains a population of non-haemopoietic mesenchymal stem cells (MSC), which support haemopoiesis and can differentiate along multiple lineages. In terms of eventual downstream application, both fetal HSC and MSC have advantages over their adult counterparts, including better intrinsic homing and engraftment, greater multipotentiality and lower immunogenicity. Fetal stem cells are less ethically contentious than embryonic stem cells and their differentiation potential appears greater than adult stem cells. Fetal stem cells represent powerful tools for exploring many aspects of cell biology and hold considerable promise as therapeutic tools for cell transplantation and ex vivo gene therapy.
Copyright © 2004 Elsevier Ltd All rights reserved.

Keyword Fetal blood progenitors
Fetal bone marrow
Fetal liver
Q-Index Code C1
Additional Notes Issue title: Stem cells in obstetrics and gynaecology

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
UQ Centre for Clinical Research Publications
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Citation counts: TR Web of Science Citation Count  Cited 65 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 86 times in Scopus Article | Citations
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Created: Mon, 23 Mar 2009, 11:17:31 EST by Maria Campbell on behalf of Faculty Of Health Sciences