Inhibitory effect of erythropoietin on contractility of human chorionic plate vessels

Jain, Venu, Lim, Maria, Longo, Monica and Fisk, Nicholas M. (2006) Inhibitory effect of erythropoietin on contractility of human chorionic plate vessels. American Journal of Obstetrics and Gynecology, 194 1: 246.e1-246.e7. doi:10.1016/j.ajog.2005.05.037

Author Jain, Venu
Lim, Maria
Longo, Monica
Fisk, Nicholas M.
Title Inhibitory effect of erythropoietin on contractility of human chorionic plate vessels
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
Publication date 2006-01
Sub-type Article (original research)
DOI 10.1016/j.ajog.2005.05.037
Volume 194
Issue 1
Start page 246.e1
End page 246.e7
Total pages 7
Place of publication St Louis, MO, U.S.
Publisher Mosby
Language eng
Subject 111402 Obstetrics and Gynaecology
1114 Paediatrics and Reproductive Medicine
Formatted abstract
Objective: Placenta is a major source of erythropoietin production in the fetus; hypoxia is associated with elevated erythropoietin levels in the fetal circulation. We investigated fetoplacental vascular reactivity after exposure to erythropoietin in vitro.
Study design: Third-order chorionic plate arteries from human term placentae were incubated in culture medium with or without erythropoietin (3 U/mL) for 24 hours. Vessels were mounted in a myograph for isometric tension recording, and their responses to vasopressors and vasorelaxants were studied.
Results: Contractile responses to endothelin-1 and the thromboxane analogue U46619 were decreased in erythropoietin-exposed vessels compared with controls. Relaxant responses to the nitric oxide donor sodium nitroprusside and the phosphodiesterase inhibitor papaverine were not influenced by erythropoietin.
Conclusion: Exposure to elevated levels of erythropoietin has an previous terminhibitory effectnext term on contractile responses in human placental chorionic plate arteries. We speculate that this may improve fetoplacental perfusion in hypoxic fetuses with elevated erythropoietin production.
Copyright © 2006 Mosby, Inc. All rights reserved.

Keyword Chorionic plate artery
Human placenta
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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