A structural study of hybrid organosilica materials for colloid-based DNA biosensors

Corrie, Simon R., Vogel, Robert, Keen, Imelda, Jack, Kevin, Kozak, Darby, Lawrie, Gwendolyn A., Battersby, Bronwyn J., Fredericks, Peter and Trau, Matt (2008) A structural study of hybrid organosilica materials for colloid-based DNA biosensors. Journals of Materials Chemistry, 18 5: 523-529. doi:10.1039/b714309e

Author Corrie, Simon R.
Vogel, Robert
Keen, Imelda
Jack, Kevin
Kozak, Darby
Lawrie, Gwendolyn A.
Battersby, Bronwyn J.
Fredericks, Peter
Trau, Matt
Title A structural study of hybrid organosilica materials for colloid-based DNA biosensors
Journal name Journals of Materials Chemistry   Check publisher's open access policy
ISSN 0959-9428
Publication date 2008
Sub-type Article (original research)
DOI 10.1039/b714309e
Open Access Status Not Open Access
Volume 18
Issue 5
Start page 523
End page 529
Total pages 7
Place of publication Cambridge, England
Publisher Royal Society of Chemistry
Collection year 2009
Language eng
Subject C1
030301 Chemical Characterisation of Materials
970103 Expanding Knowledge in the Chemical Sciences
Abstract Organosilane hybrid materials are of interest in the development of diagnostic devices and drug-delivery applications. Here we report a spectroscopic study involving the chemical and structural modification of thiol-functionalised organosilica particles with aminosilane to produce a bifunctional silica hybrid. The aminosilane was revealed to be distributed throughout the microsphere as opposed to being surface-localised as is commonly reported for modifications of pure silica. Spectroscopic methods including NMR, XPS, Ninhydrin and gravimetric measurements were employed to investigate the surface and internal elemental composition of the particles independently. A multiplexed model bioassay is presented to demonstrate the advantage of organosilane bifunctionality, enabling separate covalent attachment strategies for both homogeneous incorporation of fluorescent dyes and surface-specific biomolecule attachment. This study represents an advance in the understanding of organosilane chemistry resulting in versatile materials with a range of functionalities for covalent attachment.
Keyword Organosilane hybrid materials
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Fri, 20 Mar 2009, 15:47:56 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences