Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort

Rowe, Julie, Kusel, Merci, Holt, Barbara, J., Suriyaarachchi, Devinda, Serralha, Michael, Hollams, Elysia, Yerkovich, Stephanie, T., Subrata, Lily, S., Ladyman, Claire, Sadowska, Agata, Gillett, Jamie, Fisher, Elizabeth, Loh, Richard, Soderstrom, Lars, Ahlstedt, Saffan, Sly, Peter, D. and Holt, Patrick, G. (2007) Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort. Journal of Allergy and Clinical Immunology, 119 5: 1164-1173. doi:10.1016/j.jaci.2007.02.016

Author Rowe, Julie
Kusel, Merci
Holt, Barbara, J.
Suriyaarachchi, Devinda
Serralha, Michael
Hollams, Elysia
Yerkovich, Stephanie, T.
Subrata, Lily, S.
Ladyman, Claire
Sadowska, Agata
Gillett, Jamie
Fisher, Elizabeth
Loh, Richard
Soderstrom, Lars
Ahlstedt, Saffan
Sly, Peter, D.
Holt, Patrick, G.
Title Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.jaci.2007.02.016
Volume 119
Issue 5
Start page 1164
End page 1173
Total pages 10
Place of publication Milwaukee, WI, United States
Publisher Mosby
Language eng
Abstract Background The timing of allergen sensitization is controversial, with conflicting evidence suggesting transplacental priming versus exclusively postnatal priming. Resolution of this question is important in relation to rational design of allergy prevention strategies, particularly the issue of allergen avoidance during pregnancy. Objective To elucidate the kinetics of sensitization in high-risk children during their first 2 years of life. Methods We prospectively studied house dust mite (HDM)–specific IgE and IgG4 antibody production and associated T-cell immunity in a cohort of 200 high-risk infants. Parallel antibody studies tracked responses against a broader panel of inhalant and dietary allergens including peanut. Results HDM-induced TH2 responses in PBMC from 6 months onward, particularly IL-4 and IL-5, correlated increasingly strongly with sensitization outcomes at 2 years, and a contrasting negative relationship was observed with IFN-γ response capacity. HDM-induced T-cell responses in cord blood, although common, were unrelated to subsequent sensitization. Transient HDM-IgE (and IgG4) production frequently peaked at 6 or 12 months before returning to baseline, which suggests the onset of protective tolerance. This finding contrasted with progressively increasing HDM-IgE titers in children sensitized by 2 years of age. Comparably contrasting patterns were observed in peanut-specific responses in sensitized versus nonsensitized children. Conclusion Priming of TH2 responses associated with persistent HDM-IgE production occurs entirely postnatally, as HDM reactivity in cord blood seems nonspecific and is unrelated to subsequent development of allergen-specific TH2 memory or IgE.
Keyword Atopy
T-cell memory
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Created: Thu, 19 Mar 2009, 10:51:24 EST by Ms Julie Schofield on behalf of School of Medicine