Specific glial populations regulate hippocampal morphogenesis

Barry, Guy, Michael Piper, Lindwall, Charlotta, Moldrich, Randal, Mason, Sharon, Little, Erica, Sarkar, Anindita, Tole, Shubha, Gronostajski, Richard M. and Richards, Linda J. (2008) Specific glial populations regulate hippocampal morphogenesis. The Journal of Neuroscience, 28 47: 12328-12340. doi:10.1523/JNEUROSCI.4000-08.2008

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Author Barry, Guy
Michael Piper
Lindwall, Charlotta
Moldrich, Randal
Mason, Sharon
Little, Erica
Sarkar, Anindita
Tole, Shubha
Gronostajski, Richard M.
Richards, Linda J.
Title Specific glial populations regulate hippocampal morphogenesis
Journal name The Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2008-11-19
Year available 2008
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.4000-08.2008
Open Access Status File (Publisher version)
Volume 28
Issue 47
Start page 12328
End page 12340
Total pages 13
Editor John H. R. Maunsell
Place of publication Washington D.C. USA
Publisher Society for Neuroscience
Collection year 2009
Language eng
Subject C1
110902 Cellular Nervous System
110903 Central Nervous System
920111 Nervous System and Disorders
060103 Cell Development, Proliferation and Death
Abstract The hippocampus plays an integral role in spatial navigation, learning and memory, and is a major site for adult neurogenesis. Critical to these functions is the proper organization of the hippocampus during development. Radial glia are known to regulate hippocampal formation, but their precise function in this process is yet to be defined. We find that in Nuclear Factor I b (Nfib)-deficient mice, a subpopulation of glia from the ammonic neuroepithelium of the hippocampus fail to develop. This results in severe morphological defects, including a failure of the hippocampal fissure, and subsequently the dentate gyrus, to form. As in wild-type mice, immature nestin-positive glia, which encompass all types of radial glia, populate the hippocampus in Nfib-deficient mice at embryonic day 15. However, these fail to mature into GLAST- and GFAP-positive glia, and the supragranular glial bundle is absent. In contrast, the fimbrial glial bundle forms, but alone is insufficient for proper hippocampal morphogenesis. Dentate granule neurons are present in the mutant hippocampus but their migration is aberrant, likely resulting from the lack of the complete radial glial scaffold usually provided by both glial bundles. These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis.
Keyword hippocampal fissure
dentate gyrus
glial development
supragranular bundle
neuronal migration
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2009 Higher Education Research Data Collection
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
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Created: Wed, 18 Mar 2009, 17:40:05 EST by Debra McMurtrie on behalf of Queensland Brain Institute